Literature DB >> 18264112

HP1-mediated silencing targets Pol II coactivator complexes.

Andrea Smallwood1, Joshua C Black, Naoko Tanese, Sriharsa Pradhan, Michael Carey.   

Abstract

Little is known of the specific biochemical mechanism by which heterochromatin protein 1 (HP1) inactivates a gene. We analyzed HP1-mediated inhibition of preinitiation complex (PIC) assembly in vitro on chromatin templates regulated by GAL4-VP16 or Sp1. HP1 blocked key subunits of the TFIID and Mediator coactivator complexes. Notably, binding of the same subunits was inhibited by HP1 on the Sp1-regulated survivin gene in vivo upon DNA damage-induced silencing.

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Year:  2008        PMID： 18264112     DOI： 10.1038/nsmb.1385

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  16 in total

Review 1.  Promoter-associated RNAs and promoter-targeted RNAs.

Authors:  Bing-Xue Yan; Jin-Xia Ma
Journal:  Cell Mol Life Sci       Date:  2012-03-14       Impact factor: 9.261

2.  Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy.

Authors:  Sarah Franklin; Michael J Zhang; Haodong Chen; Anna K Paulsson; Scherise A Mitchell-Jordan; Yifeng Li; Peipei Ping; Thomas M Vondriska
Journal:  Mol Cell Proteomics       Date:  2010-08-31       Impact factor: 5.911

Review 3.  Regulation of DNA replication by chromatin structures: accessibility and recruitment.

Authors:  Makoto T Hayashi; Hisao Masukata
Journal:  Chromosoma       Date:  2010-08-03       Impact factor: 4.316

4.  Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).

Authors:  Shuichiro Higo; Yoshihiro Asano; Hisakazu Kato; Satoru Yamazaki; Atsushi Nakano; Osamu Tsukamoto; Osamu Seguchi; Mitsutoshi Asai; Masanori Asakura; Hiroshi Asanuma; Shoji Sanada; Tetsuo Minamino; Issei Komuro; Masafumi Kitakaze; Seiji Takashima
Journal:  J Biol Chem       Date:  2010-08-01       Impact factor: 5.157

5.  HP1α is not necessary for the structural maintenance of centromeric heterochromatin.

Authors:  Artem K Velichko; Omar L Kantidze; Sergey V Razin
Journal:  Epigenetics       Date:  2011-03-01       Impact factor: 4.528

6.  Role of the epigenetic regulator HP1γ in the control of embryonic stem cell properties.

Authors:  Maïa Caillier; Sandrine Thénot; Violaine Tribollet; Anne-Marie Birot; Jacques Samarut; Anne Mey
Journal:  PLoS One       Date:  2010-11-15       Impact factor: 3.240

7.  Polycomb repressive complex 1 (PRC1) disassembles RNA polymerase II preinitiation complexes.

Authors:  Lynn Lehmann; Roberto Ferrari; Ajay A Vashisht; James A Wohlschlegel; Siavash K Kurdistani; Michael Carey
Journal:  J Biol Chem       Date:  2012-08-21       Impact factor: 5.157

Review 8.  The emerging role of HP1 in the DNA damage response.

Authors:  Christoffel Dinant; Martijn S Luijsterburg
Journal:  Mol Cell Biol       Date:  2009-10-05       Impact factor: 4.272

Review 9.  The Mediator complex: a central integrator of transcription.

Authors:  Benjamin L Allen; Dylan J Taatjes
Journal:  Nat Rev Mol Cell Biol       Date:  2015-02-18       Impact factor: 94.444

Review 10.  The Mediator complex and transcription regulation.

Authors:  Zachary C Poss; Christopher C Ebmeier; Dylan J Taatjes
Journal:  Crit Rev Biochem Mol Biol       Date:  2013-10-03       Impact factor: 8.250
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