Literature DB >> 18262415

Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi.

Nanting Ni1, Gaurav Choudhary, Minyong Li, Binghe Wang.   

Abstract

Bacteria can coordinate community-wide behaviors through quorum sensing, that is, the secretion and sensing of autoinducer (AI) molecules. Bacterial quorum sensing is implicated in the regulation of pathologically relevant events such as biofilm formation, bacterial virulence, and drug resistance. Inhibitors of bacterial quorum sensing could therefore be useful therapeutics. Herein we report for the first time the discovery of several pyrogallol compounds as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi.

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Year:  2008        PMID： 18262415     DOI： 10.1016/j.bmcl.2008.01.081

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  24 in total

1.  Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols.

Authors:  Stephen J Glynn; Kevin J Gaffney; Marcos A Sainz; Stan G Louie; Nicos A Petasis
Journal:  Org Biomol Chem       Date:  2015-04-07       Impact factor: 3.876

2.  An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues.

Authors:  Colin A Lowery; Junguk Park; Gunnar F Kaufmann; Kim D Janda
Journal:  J Am Chem Soc       Date:  2008-06-25       Impact factor: 15.419

Review 3.  Exploiting quorum sensing to confuse bacterial pathogens.

Authors:  Breah LaSarre; Michael J Federle
Journal:  Microbiol Mol Biol Rev       Date:  2013-03       Impact factor: 11.056

Review 4.  Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?

Authors:  Alejandro Beceiro; María Tomás; Germán Bou
Journal:  Clin Microbiol Rev       Date:  2013-04       Impact factor: 26.132

Review 5.  Antibiofilm agents: A new perspective for antimicrobial strategy.

Authors:  Xi-Hui Li; Joon-Hee Lee
Journal:  J Microbiol       Date:  2017-09-28       Impact factor: 3.422

6.  The apparent quorum-sensing inhibitory activity of pyrogallol is a side effect of peroxide production.

Authors:  Tom Defoirdt; Gde Sasmita Julyantoro Pande; Kartik Baruah; Peter Bossier
Journal:  Antimicrob Agents Chemother       Date:  2013-04-01       Impact factor: 5.191

7.  Medicinal chemistry as a conduit for the modulation of quorum sensing.

Authors:  Colin A Lowery; Nicholas T Salzameda; Daisuke Sawada; Gunnar F Kaufmann; Kim D Janda
Journal:  J Med Chem       Date:  2010-11-11       Impact factor: 7.446

8.  Small molecule inhibitors of AI-2 signaling in bacteria: state-of-the-art and future perspectives for anti-quorum sensing agents.

Authors:  Min Guo; Sonja Gamby; Yue Zheng; Herman O Sintim
Journal:  Int J Mol Sci       Date:  2013-08-29       Impact factor: 5.923

9.  A pro-drug approach for selective modulation of AI-2-mediated bacterial cell-to-cell communication.

Authors:  Min Guo; Sonja Gamby; Shizuka Nakayama; Jacqueline Smith; Herman O Sintim
Journal:  Sensors (Basel)       Date:  2012-03-21       Impact factor: 3.576

Review 10.  Towards microbial fermentation metabolites as markers for health benefits of prebiotics.

Authors:  Kristin A Verbeke; Alan R Boobis; Alessandro Chiodini; Christine A Edwards; Anne Franck; Michiel Kleerebezem; Arjen Nauta; Jeroen Raes; Eric A F van Tol; Kieran M Tuohy
Journal:  Nutr Res Rev       Date:  2015-06       Impact factor: 7.800
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