Literature DB >> 18259947

Effect of the p53 codon 72 and intron 3 polymorphisms on non-small cell lung cancer (NSCLC) prognosis.

Laura Boldrini1, Silvia Gisfredi, Silvia Ursino, Marco Lucchi, Giordana Greco, Alfredo Mussi, Valentina Donati, Gabriella Fontanini.   

Abstract

A total of 42 polymorphisms have been identified in the TP53 gene. The polymorphic site of p53 at codon 72 in exon 4 and p53PIN3, a 16 bp insertion/duplication in intron 3, are the most studied. We tested p53PIN3 and the combined effect of the p53 codon72 and PIN3 polymorphisms on prognosis in 101 NSCLC cases. This study provides support for the prognostic effects of the multi-variant alleles from p53 exon 4 and intron 3, resulting in a significantly poorer prognosis in NSCLC. This approach highlights the value of examining multiple polymorphisms in genes to improve survival estimates.

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Year:  2008        PMID： 18259947     DOI： 10.1080/07357900701788023

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  5 in total

Review 1.  p53 polymorphisms: cancer implications.

Authors:  Catherine Whibley; Paul D P Pharoah; Monica Hollstein
Journal:  Nat Rev Cancer       Date:  2009-02       Impact factor: 60.716

2.  p53 codon 72 polymorphism as a progression index for bladder cancer.

Authors:  Hung-Yu Lin; Chun-Hsiung Huang; Tsan-Jung Yu; Wen-Jen Wu; Ming-Chang Yang; For-Wey Lung
Journal:  Oncol Rep       Date:  2011-12-22       Impact factor: 3.906

3.  What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II - information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy.

Authors:  Rumena Petkova; Pavlina Chelenkova; Elena Georgieva; Stoian Chakarov
Journal:  Biotechnol Biotechnol Equip       Date:  2014-01-02       Impact factor: 1.632

Review 4.  Polymorphisms in p53 and the p53 pathway: roles in cancer susceptibility and response to treatment.

Authors:  Roman Hrstka; Philip J Coates; Borivoj Vojtesek
Journal:  J Cell Mol Med       Date:  2009-03       Impact factor: 5.310

5.  Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.

Authors:  J Chang-Claude; C B Ambrosone; C Lilla; S Kropp; I Helmbold; D von Fournier; W Haase; M-L Sautter-Bihl; F Wenz; P Schmezer; O Popanda
Journal:  Br J Cancer       Date:  2009-04-14       Impact factor: 7.640
  5 in total

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