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Literature DB >> 1825940

Decreased expression of complement receptor type 2 (CR2) on neoplastic B cells of chronic lymphocytic leukaemia.

Abstract

Neoplastic cells from 49 patients with B cell chronic lymphocytic leukaemia (B-CLL) were studied and compared with normal peripheral and tonsillar B cells using CD21 monoclonal antibodies. Membrane expression of CR2 was quantified by calibrated flow cytometry and by binding analysis with radiolabelled antibody. Both assays indicate that B-CLL cells express only 30% of the CR2 found on normal B cells. These findings are further evidence of the aberrant phenotype of B-CLL cells.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1991 PMID： 1825940 PMCID： PMC1535322 DOI： 10.1111/j.1365-2249.1991.tb05655.x

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

41 in total

Review 1. Differentiation capacity and other properties of the leukemic cells of chronic lymphocytic leukemia.

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Journal: Immunol Rev Date: 1979 Impact factor: 12.988

2. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

Authors: P L Ey; S J Prowse; C R Jenkin
Journal: Immunochemistry Date: 1978-07

3. An improved rosetting assay for detection of human T lymphocytes.

Authors: M E Kaplan; C Clark
Journal: J Immunol Methods Date: 1974-07 Impact factor: 2.303

4. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia.

Authors: H M Grey; E Rabellino; B Pirofsky
Journal: J Clin Invest Date: 1971-11 Impact factor: 14.808

5. Some chronic lymphocytic leukemia cells bearing surface immunoglobulins share determinants with T cells.

Authors: L Boumsell; A Bernard; V Lepage; L Degos; J Lemerle; J Dausset
Journal: Eur J Immunol Date: 1978-12 Impact factor: 5.532

6. Paraformaldehyde fixation of hematopoietic cells for quantitative flow cytometry (FACS) analysis.

Authors: L L Lanier; N L Warner
Journal: J Immunol Methods Date: 1981 Impact factor: 2.303

7. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.

Authors: P J Fraker; J C Speck
Journal: Biochem Biophys Res Commun Date: 1978-02-28 Impact factor: 3.575

8. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis.

Authors: J L Binet; A Auquier; G Dighiero; C Chastang; H Piguet; J Goasguen; G Vaugier; G Potron; P Colona; F Oberling; M Thomas; G Tchernia; C Jacquillat; P Boivin; C Lesty; M T Duault; M Monconduit; S Belabbes; F Gremy
Journal: Cancer Date: 1981-07-01 Impact factor: 6.860

9. Two different complement receptors on human lymphocytes. One specific for C3b and one specific for C3b inactivator-cleaved C3b.

Authors: G D Ross; M J Polley; E M Rabellino; H M Grey
Journal: J Exp Med Date: 1973-10-01 Impact factor: 14.307

5. A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL.

Authors: Eva-Maria Nichols; Rachel Jones; Rachael Watson; Chris J Pepper; Chris Fegan; Kevin J Marchbank
Journal: Oncotarget Date: 2015-10-20

5 in total

Decreased expression of complement receptor type 2 (CR2) on neoplastic B cells of chronic lymphocytic leukaemia.

Review 1. Differentiation capacity and other properties of the leukemic cells of chronic lymphocytic leukemia.

2. Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-sepharose.

3. An improved rosetting assay for detection of human T lymphocytes.

4. Immunoglobulins on the surface of lymphocytes. IV. Distribution in hypogammaglobulinemia, cellular immune deficiency, and chronic lymphatic leukemia.

5. Some chronic lymphocytic leukemia cells bearing surface immunoglobulins share determinants with T cells.

6. Paraformaldehyde fixation of hematopoietic cells for quantitative flow cytometry (FACS) analysis.

7. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.

8. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis.

9. Two different complement receptors on human lymphocytes. One specific for C3b and one specific for C3b inactivator-cleaved C3b.

10. Occurrence of surface IgM, IgD, and free light chains of human lymphocytes.

1. Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis.

2. Contribution of follicular dendritic cells to persistent HIV viremia.

3. Complement activation by malignant B cells from patients with chronic lymphocytic leukaemia (CLL).

4. B-cell activity in children with malaria.

5. A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL.