Literature DB >> 18258980

Clinical application of the 70-gene profile: the MINDACT trial.

Fatima Cardoso1, Laura Van't Veer, Emiel Rutgers, Sherene Loi, Stella Mook, Martine J Piccart-Gebhart.   

Abstract

The 70-gene profile is a new prognostic tool that has the potential to greatly improve risk assessment and treatment decision making for early breast cancer. Its prospective validation is currently ongoing through the MINDACT (Microarray in Node-Negative Disease May Avoid Chemotherapy) trial, a 6,000-patient randomized, multicentric trial. This article reviews the several steps in the development of the profile from its discovery to its clinical validation.

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Year:  2008        PMID： 18258980     DOI： 10.1200/JCO.2007.14.3222

Source DB:  PubMed          Journal:  J Clin Oncol        ISSN： 0732-183X            Impact factor:   44.544


  152 in total

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Authors:  John P A Ioannidis; Muin J Khoury
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3.  The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer.

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4.  Gene-expression profiling in breast cancer: bespoke cancer therapy or more fiction than science?

Authors:  M Barry; M R Kell
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Authors:  Chungyeul Kim; Soonmyung Paik
Journal:  Nat Rev Clin Oncol       Date:  2010-05-04       Impact factor: 66.675

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Authors:  Jyothi Subramanian; Richard Simon
Journal:  J Natl Cancer Inst       Date:  2010-03-16       Impact factor: 13.506

8.  Surgical oncology: why biopsying metastatic breast cancer should be routine.

Authors:  Anand Sharma; Tim Crook; Alastair Thompson; Carlo Palmieri
Journal:  Nat Rev Clin Oncol       Date:  2010-02       Impact factor: 66.675

9.  Adjuvant Systemic Therapy, Quo Vadis? Patient Selection, Prognostic and Predictive Factors.

Authors:  Fatima Cardoso
Journal:  Breast Care (Basel)       Date:  2008-12-02       Impact factor: 2.860

10.  Multigene Assays for Classification, Prognosis, and Prediction in Breast Cancer: a Critical Review on the Background and Clinical Utility.

Authors:  P Sinn; S Aulmann; R Wirtz; S Schott; F Marmé; Z Varga; A Lebeau; H Kreipe; A Schneeweiss
Journal:  Geburtshilfe Frauenheilkd       Date:  2013-09       Impact factor: 2.915
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