Literature DB >> 18258202

Angiotensin II and III suppress food intake via angiotensin AT(2) receptor and prostaglandin EP(4) receptor in mice.

Kousaku Ohinata1, Yoko Fujiwara, Shingo Fukumoto, Masaru Iwai, Masatsugu Horiuchi, Masaaki Yoshikawa.   

Abstract

Intracerebroventricularly administered angiotensin (Ang) II and III dose-dependently suppressed food intake in mice and their anorexigenic activities were inhibited by AT(2) receptor-selective antagonist. Ang II did not suppress food intake in AT(2) receptor-knockout mice, while it did significantly in wild-type and AT(1) receptor-knockout mice. The suppression of food intake in AT(1) receptor-knockout mice was smaller than that in wild-type. The anorexigenic activities of Ang II and III were also blocked by a selective antagonist for prostaglandin EP(4) receptor. Taken together, centrally administered Ang II and III may decrease food intake through AT(2) receptor with partial involvement of AT(1) receptor, followed by EP(4) receptor activation, which is a novel pathway regulating food intake.

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Year:  2008        PMID： 18258202     DOI： 10.1016/j.febslet.2008.01.054

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Control of energy balance by the brain renin-angiotensin system.

Authors:  Kristin E Claflin; Justin L Grobe
Journal:  Curr Hypertens Rep       Date:  2015-05       Impact factor: 5.369

Review 2.  The intricacies of the renin-angiotensin-system in metabolic regulation.

Authors:  Erin B Bruce; Annette D de Kloet
Journal:  Physiol Behav       Date:  2016-11-22

3.  Angiotensin II type 2 receptor promotes adipocyte differentiation and restores adipocyte size in high-fat/high-fructose diet-induced insulin resistance in rats.

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Journal:  Am J Physiol Endocrinol Metab       Date:  2012-11-13       Impact factor: 4.310

4.  Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation.

Authors:  Eva H C Tang; Eugenia Shvartz; Koichi Shimizu; Viviane Z Rocha; Chunyu Zheng; Daiju Fukuda; Guo-Ping Shi; Galina Sukhova; Peter Libby
Journal:  Arterioscler Thromb Vasc Biol       Date:  2010-11-18       Impact factor: 8.311

5.  ANGT_HUMAN[448-462], an Anorexigenic Peptide Identified Using Plasma Peptidomics.

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Review 6.  Opposing tissue-specific roles of angiotensin in the pathogenesis of obesity, and implications for obesity-related hypertension.

Authors:  Nicole K Littlejohn; Justin L Grobe
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2015-10-21       Impact factor: 3.619

7.  MRI/DTI of the Brain Stem Reveals Reversible and Irreversible Disruption of the Baroreflex Neural Circuits: Clinical Implications.

Authors:  Chia-Hao Su; Ching-Yi Tsai; Alice Y W Chang; Julie Y H Chan; Samuel H H Chan
Journal:  Theranostics       Date:  2016-04-11       Impact factor: 11.556

8.  Bone-Targeted Delivery of Novokinin as an Alternative Treatment Option for Rheumatoid Arthritis.

Authors:  Arina Ranjit; Sana Khajeh Pour; Ali Aghazadeh-Habashi
Journal:  Pharmaceutics       Date:  2022-08-12       Impact factor: 6.525

9.  The Angiotensin II Type 2 Receptor in Brain Functions: An Update.

Authors:  Marie-Odile Guimond; Nicole Gallo-Payet
Journal:  Int J Hypertens       Date:  2012-12-25       Impact factor: 2.420
  9 in total

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