Literature DB >> 18258191

Biochemical characterization of a chromosomal toxin-antitoxin system in Mycobacterium tuberculosis.

Longxuan Zhao1, Junjie Zhang.   

Abstract

In the present paper, we report the biochemical characterization of a chromosomal toxin-antitoxin (TA) system in Mycobacterium tuberculosis, consisting of the Rv1991c gene and its upstream open reading frame (ORF) termed Rv1991a. Rv1991c was characterized as a toxin with ribonuclease activity and Rv1991a as the antitoxin against Rv1991c. Rv1991a interacted with Rv1991c to form a complex. A promoter located immediately upstream of Rv1991a was identified. Both Rv1991a and the Rv1991a-Rv1991c complex were able to bind to the promoter region of the Rv1991a-Rv1991c operon, indicating that the expression of the Rv1991a-Rv1991c operon can be autoregulated.

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Year:  2008        PMID： 18258191     DOI： 10.1016/j.febslet.2008.01.045

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

1.  Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival.

Authors:  Rebekah Frampton; Raphael B M Aggio; Silas G Villas-Bôas; Vickery L Arcus; Gregory M Cook
Journal:  J Biol Chem       Date:  2011-12-23       Impact factor: 5.157

2.  The chromosomal mazEF locus of Streptococcus mutans encodes a functional type II toxin-antitoxin addiction system.

Authors:  Mohammad Adnan Syed; Stephanie Koyanagi; Eesha Sharma; Marie-Claude Jobin; Alexander F Yakunin; Céline M Lévesque
Journal:  J Bacteriol       Date:  2010-12-23       Impact factor: 3.490

Review 3.  Updating and curating metabolic pathways of TB.

Authors:  Richard A Slayden; Mary Jackson; Jeremy Zucker; Melissa V Ramirez; Clinton C Dawson; Rebecca Crew; Nicole S Sampson; Suzanne T Thomas; Neema Jamshidi; Peter Sisk; Ron Caspi; Dean C Crick; Michael R McNeil; Martin S Pavelka; Michael Niederweis; Axel Siroy; Valentina Dona; Johnjoe McFadden; Helena Boshoff; Jocelyne M Lew
Journal:  Tuberculosis (Edinb)       Date:  2013-02-01       Impact factor: 3.131

4.  Crystallization and preliminary X-ray analysis of two variants of the Escherichia coli O157 ParE2-PaaA2 toxin-antitoxin complex.

Authors:  Yann G J Sterckx; Sarah Haesaerts; Laurence Van Melderen; Remy Loris
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-08-27       Impact factor: 1.056

5.  Analyzing the regulatory role of the HigA antitoxin within Mycobacterium tuberculosis.

Authors:  Amanda S Fivian-Hughes; Elaine O Davis
Journal:  J Bacteriol       Date:  2010-06-28       Impact factor: 3.490

6.  The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic tolerance.

Authors:  Ramandeep Singh; Clifton E Barry; Helena I M Boshoff
Journal:  J Bacteriol       Date:  2010-01-08       Impact factor: 3.490

7.  Three Mycobacterium tuberculosis Rel toxin-antitoxin modules inhibit mycobacterial growth and are expressed in infected human macrophages.

Authors:  Shaleen B Korch; Heidi Contreras; Josephine E Clark-Curtiss
Journal:  J Bacteriol       Date:  2008-12-29       Impact factor: 3.490

8.  Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I.

Authors:  Feng Huang; Zheng-Guo He
Journal:  Nucleic Acids Res       Date:  2010-08-19       Impact factor: 16.971

9.  Recent advancements in toxin and antitoxin systems involved in bacterial programmed cell death.

Authors:  Ming-Xi Hu; Xiao Zhang; Er-Li Li; Yong-Jun Feng
Journal:  Int J Microbiol       Date:  2010-12-27

10.  Characterization of a chromosomal type II toxin-antitoxin system mazEaFa in the Cyanobacterium Anabaena sp. PCC 7120.

Authors:  Degang Ning; Yan Jiang; Zhaoying Liu; Qinggang Xu
Journal:  PLoS One       Date:  2013-02-25       Impact factor: 3.240
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