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Literature DB >> 18257129

Mitochondrion and its related disorders: making a comeback.

Abstract

The great majority of genetic disorders are caused by defects in the nuclear genome. However, some significant diseases are the result of mitochondrial mutations. Because of the unique features of the mitochondria, these diseases display characteristic modes of inheritance and a large degree of phenotypic variability. Recent studies have suggested that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer.

Entities: Disease

Mesh：

Substances：

Year: 2008 PMID： 18257129 PMCID： PMC2225489 DOI： 10.1631/jzus.B0710621

Source DB: PubMed Journal: J Zhejiang Univ Sci B ISSN： 1673-1581 Impact factor: 3.066

15 in total

1. Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA.

Authors: R M Andrews; I Kubacka; P F Chinnery; R N Lightowlers; D M Turnbull; N Howell
Journal: Nat Genet Date: 1999-10 Impact factor: 38.330

2. Paternal inheritance of mitochondrial DNA.

Authors: Marianne Schwartz; John Vissing
Journal: N Engl J Med Date: 2002-08-22 Impact factor: 91.245

3. Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study.

Authors: Petri Luoma; Atle Melberg; Juha O Rinne; Jyrki A Kaukonen; Nina N Nupponen; Richard M Chalmers; Anders Oldfors; Ilkka Rautakorpi; Leena Peltonen; Kari Majamaa; Hannu Somer; Anu Suomalainen
Journal: Lancet Date: 2004 Sep 4-10 Impact factor: 79.321

4. Identification of an X-chromosomal locus and haplotype modulating the phenotype of a mitochondrial DNA disorder.

Authors: Gavin Hudson; Sharon Keers; Patrick Yu-Wai-Man; Philip Griffiths; Kirsi Huoponen; Marja-Liisa Savontaus; Eeva Nikoskelainen; Massimo Zeviani; Franco Carrara; Rita Horvath; Veronika Karcagi; Liesbeth Spruijt; I F M de Coo; Hubert J M Smeets; Patrick F Chinnery
Journal: Am J Hum Genet Date: 2005-10-11 Impact factor: 11.025

Review 5. Mitochondria: dynamic organelles in disease, aging, and development.

Authors: David C Chan
Journal: Cell Date: 2006-06-30 Impact factor: 41.582

6. Systematic identification of human mitochondrial disease genes through integrative genomics.

Authors: Sarah Calvo; Mohit Jain; Xiaohui Xie; Sunil A Sheth; Betty Chang; Olga A Goldberger; Antonella Spinazzola; Massimo Zeviani; Steven A Carr; Vamsi K Mootha
Journal: Nat Genet Date: 2006-04-02 Impact factor: 38.330

7. Yield of mtDNA mutation analysis in 2,000 patients.

Authors: M H Liang; L J Wong
Journal: Am J Med Genet Date: 1998-06-05

8. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.

Authors: D C Wallace; G Singh; M T Lott; J A Hodge; T G Schurr; A M Lezza; L J Elsas; E K Nikoskelainen
Journal: Science Date: 1988-12-09 Impact factor: 47.728

Review 9. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.

Authors: Douglas C Wallace
Journal: Annu Rev Genet Date: 2005 Impact factor: 16.830

3. Alterations in enterocyte mitochondrial respiratory function and enzyme activities in gastrointestinal dysfunction following brain injury.

Authors: Ke-Jun Zhu; Hong Huang; Hui Chu; Hang Yu; Shi-Ming Zhang
Journal: World J Gastroenterol Date: 2014-07-28 Impact factor: 5.742

3 in total