OBJECTIVE: To examine the role of the big five personality domains (Neuroticism, Extraversion, Openness, Agreeableness, Conscientiousness) and their respective facets and profiles on change in CD4 and log HIV-RNA copies/ml (VL) over 4 years. The examination of psychosocial predictors of disease progression in human immunodeficiency virus (HIV) has focused primarily on depression, coping, and stress, with little attention paid to stable individual differences. METHODS: A diverse sample of HIV-seropositive patients (n = 104) completed personality assessment (NEO-PI-R), underwent comprehensive psychological assessment and blood samples every 6 months for 4 years. Linear rates of change for CD4 cells and VL were modeled using Hierarchical Linear Modeling controlling for antiretrovirals (time dependent covariate), initial disease status, age, gender, ethnicity, and education. RESULTS: Domains that were significantly associated with slower disease progression over 4 years included Openness (CD4, VL), Extraversion (CD4, VL), and Conscientiousness (VL). Facets of the above domains that were significantly related to slower disease progression were assertiveness, positive emotions, and gregariousness (Extraversion); ideas, esthetics (Openness); achievement striving and order (Conscientiousness). In addition, profile analyses suggested personality styles which seem to underscore the importance of remaining engaged (e.g., Creative Interactors (E+O+), Upbeat Optimists (N-E+), Welcomers (E+A+), Go Getters (C+E+), and Directed (N-C+)) had slower disease progression, whereas the "homebody" profile (Low Extraversion-Low Openness) was significantly associated with faster disease progression. CONCLUSIONS: These results provide good initial evidence of the relationship between personality and disease progression in HIV and suggest protective aspects of profiles of engagement. These finding may help identify those individuals at risk for poorer disease course and specify targets for psychosocial interventions.
OBJECTIVE: To examine the role of the big five personality domains (Neuroticism, Extraversion, Openness, Agreeableness, Conscientiousness) and their respective facets and profiles on change in CD4 and log HIV-RNA copies/ml (VL) over 4 years. The examination of psychosocial predictors of disease progression in human immunodeficiency virus (HIV) has focused primarily on depression, coping, and stress, with little attention paid to stable individual differences. METHODS: A diverse sample of HIV-seropositivepatients (n = 104) completed personality assessment (NEO-PI-R), underwent comprehensive psychological assessment and blood samples every 6 months for 4 years. Linear rates of change for CD4 cells and VL were modeled using Hierarchical Linear Modeling controlling for antiretrovirals (time dependent covariate), initial disease status, age, gender, ethnicity, and education. RESULTS: Domains that were significantly associated with slower disease progression over 4 years included Openness (CD4, VL), Extraversion (CD4, VL), and Conscientiousness (VL). Facets of the above domains that were significantly related to slower disease progression were assertiveness, positive emotions, and gregariousness (Extraversion); ideas, esthetics (Openness); achievement striving and order (Conscientiousness). In addition, profile analyses suggested personality styles which seem to underscore the importance of remaining engaged (e.g., Creative Interactors (E+O+), Upbeat Optimists (N-E+), Welcomers (E+A+), Go Getters (C+E+), and Directed (N-C+)) had slower disease progression, whereas the "homebody" profile (Low Extraversion-Low Openness) was significantly associated with faster disease progression. CONCLUSIONS: These results provide good initial evidence of the relationship between personality and disease progression in HIV and suggest protective aspects of profiles of engagement. These finding may help identify those individuals at risk for poorer disease course and specify targets for psychosocial interventions.
Authors: Robert S Wilson; Carlos F Mendes de Leon; Julia L Bienias; Denis A Evans; David A Bennett Journal: J Gerontol B Psychol Sci Soc Sci Date: 2004-05 Impact factor: 4.077
Authors: A E Korten; A F Jorm; Z Jiao; L Letenneur; P A Jacomb; A S Henderson; H Christensen; B Rodgers Journal: J Epidemiol Community Health Date: 1999-02 Impact factor: 3.710
Authors: Gail Ironson; Conall O'Cleirigh; Mary Ann Fletcher; Jean Philippe Laurenceau; Elizabeth Balbin; Nancy Klimas; Neil Schneiderman; George Solomon Journal: Psychosom Med Date: 2005 Nov-Dec Impact factor: 4.312
Authors: Alan J Christensen; Shawna L Ehlers; John S Wiebe; Patricia J Moran; Katherine Raichle; Karin Ferneyhough; William J Lawton Journal: Health Psychol Date: 2002-07 Impact factor: 4.267
Authors: Lauren Matukaitis Broyles; Adam J Gordon; Susan M Sereika; Christopher M Ryan; Judith A Erlen Journal: Subst Abus Date: 2011-10 Impact factor: 3.716
Authors: Magdalena I Tolea; Luigi Ferrucci; Paul T Costa; Kimberly Faulkner; Caterina Rosano; Suzanne Satterfield; Hilsa N Ayonayon; Eleanor M Simonsick Journal: J Gerontol B Psychol Sci Soc Sci Date: 2012-03-20 Impact factor: 4.077
Authors: Maria Rosaria A Muscatello; Antonio Bruno; Carmela Mento; Gianluca Pandolfo; Rocco A Zoccali Journal: World J Gastroenterol Date: 2016-07-28 Impact factor: 5.742
Authors: Roger C McIntosh; Gail Ironson; Michael Antoni; Betty Lai; Mahendra Kumar; Mary Ann Fletcher; Neil Schneiderman Journal: Int J Behav Med Date: 2017-04
Authors: Andrew J Wawrzyniak; Allan E Rodríguez; Anthony E Falcon; Anindita Chakrabarti; Alexa Parra; Jane Park; Kathleen Mercogliano; Kira Villamizar; Michael A Kolber; Daniel J Feaster; Lisa R Metsch Journal: J Acquir Immune Defic Syndr Date: 2015-05-01 Impact factor: 3.731
Authors: Angelina R Sutin; Alan B Zonderman; Luigi Ferrucci; Antonio Terracciano Journal: J Gerontol B Psychol Sci Soc Sci Date: 2013-05-18 Impact factor: 4.077