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Literature DB >> 18256159

Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice.

Myung-Soo Kang¹, Vishal Soni, Roderick Bronson, Elliott Kieff.

Abstract

To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18256159 PMCID： PMC2292993 DOI： 10.1128/JVI.02596-07

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

48 in total

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Journal: J Virol Date: 1994-09 Impact factor: 5.103

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Journal: J Exp Med Date: 1993-02-01 Impact factor: 14.307

14 in total

1. trans-Repression of protein expression dependent on the Epstein-Barr virus promoter Wp during latency.

Authors: David J Hughes; Carol A Dickerson; Marie S Shaner; Clare E Sample; Jeffery T Sample
Journal: J Virol Date: 2011-08-24 Impact factor: 5.103

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Authors: Eun Kyung Lee; Sun Young Kim; Ka-Won Noh; Eun Hye Joo; Bo Zhao; Elliott Kieff; Myung-Soo Kang
Journal: Antiviral Res Date: 2014-01-31 Impact factor: 5.970

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Journal: FEBS Lett Date: 2011-08-11 Impact factor: 4.124

Review 4. Cancers associated with human gammaherpesviruses.

Authors: Kwun Wah Wen; Linlin Wang; Joshua R Menke; Blossom Damania
Journal: FEBS J Date: 2021-09-18 Impact factor: 5.622

Review 5. Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.

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Review 6. Oncogenic mechanisms in Burkitt lymphoma.

Authors: Roland Schmitz; Michele Ceribelli; Stefania Pittaluga; George Wright; Louis M Staudt
Journal: Cold Spring Harb Perspect Med Date: 2014-02-01 Impact factor: 6.915

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Journal: Leukemia Date: 2011-03-11 Impact factor: 11.528

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Authors: Robert Valentine; Christopher W Dawson; Chunfang Hu; Khilan M Shah; Thomas J Owen; Kathryn L Date; Sonia P Maia; Jianyong Shao; John R Arrand; Lawrence S Young; John D O'Neil
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Authors: Danielle Westhoff Smith; Bill Sugden
Journal: Viruses Date: 2013-01-16 Impact factor: 5.048