| Literature DB >> 18254636 |
Thomas Hjelmgaard1, Sophie Faure, Pascale Lemoine, Bernard Viossat, David J Aitken.
Abstract
A very short and efficient synthesis of protected derivatives of APTO and AETD, the complex polyhydroxylated beta-amino acid residues present in microsclerodermins C, D, and E, is described. The targets are obtained in only five steps, in 23% and 16% overall yields, respectively. The key transformation involves the completely diastereoselective two-carbon homologation of appropriately selected intermediate chiral sulfinimines.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18254636 DOI： 10.1021/ol702962z
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005