Literature DB >> 18253536

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.

Pradeep S Pallan1, Damian Ittig, Annie Héroux, Zdzislaw Wawrzak, Christian J Leumann, Martin Egli.   

Abstract

The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.

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Year:  2007        PMID： 18253536     DOI： 10.1039/b716390h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Improving gene silencing of siRNAs via tricyclo-DNA modification.

Authors:  Damian Ittig; Samuel Luisier; Jan Weiler; Daniel Schümperli; Christian J Leumann
Journal:  Artif DNA PNA XNA       Date:  2010-07

Review 2.  The many twists and turns of DNA: template, telomere, tool, and target.

Authors:  Martin Egli; Pradeep S Pallan
Journal:  Curr Opin Struct Biol       Date:  2010-04-08       Impact factor: 6.809

3.  The Contribution of the Activation Entropy to the Gas-Phase Stability of Modified Nucleic Acid Duplexes.

Authors:  Yvonne Hari; Branislav Dugovič; Alena Istrate; Annabel Fignolé; Christian J Leumann; Stefan Schürch
Journal:  J Am Soc Mass Spectrom       Date:  2016-04-14       Impact factor: 3.109

4.  Insights from crystal structures into the opposite effects on RNA affinity caused by the S- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic acid.

Authors:  Pradeep S Pallan; Jinghua Yu; Charles R Allerson; Eric E Swayze; Punit Seth; Martin Egli
Journal:  Biochemistry       Date:  2011-12-29       Impact factor: 3.162

Review 5.  Crystallographic studies of chemically modified nucleic acids: a backward glance.

Authors:  Martin Egli; Pradeep S Pallan
Journal:  Chem Biodivers       Date:  2010-01       Impact factor: 2.408

6.  A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.

Authors:  Feng Wang; Feng Li; Manjori Ganguly; Luis A Marky; Barry Gold; Martin Egli; Michael P Stone
Journal:  Biochemistry       Date:  2008-06-13       Impact factor: 3.162

7.  Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes.

Authors:  Damian Ittig; Anna-Barbara Gerber; Christian J Leumann
Journal:  Nucleic Acids Res       Date:  2010-08-17       Impact factor: 16.971

8.  NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance.

Authors:  Andrei Istrate; Silke Johannsen; Alena Istrate; Roland K O Sigel; Christian J Leumann
Journal:  Nucleic Acids Res       Date:  2019-05-21       Impact factor: 16.971

9.  Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.

Authors:  Guillermo Vasquez; Graeme C Freestone; W Brad Wan; Audrey Low; Cheryl Li De Hoyos; Jinghua Yu; Thazha P Prakash; Michael E Ǿstergaard; Xue-Hai Liang; Stanley T Crooke; Eric E Swayze; Michael T Migawa; Punit P Seth
Journal:  Nucleic Acids Res       Date:  2021-02-26       Impact factor: 16.971
  9 in total

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