Literature DB >> 182526

On the mineralocorticoid and hypertensogenic properties of 16beta-hydroxy-dehydroepiandrosterone.

C Gomez-Sanchez, O B Holland, C E Hall, S Ayachi.   

Abstract

Dosages of either 1 or 2 mg daily of 16beta-hydroxy-dehydroepiandrosterone, given to mononephrectomized, salt-loaded female rats, had no detectable effect upon saline consumption, blood pressure, kallikrein excretion or heart and kidney weight. Its alleged mineralocorticoid properties, as judged by these criteria, were not demonstrable.

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Year:  1976        PMID： 182526     DOI： 10.1007/bf01933976

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  PLASMA RENIN IN A CASE OF CONN'S SYNDROME WITH FIBRINOID LESIONS: USE OF SPINONOLACTONE IN TREATMENT.

Authors:  J J BROWN; D L DAVIES; A F LEVER; W S PEART; J I ROBERTSON
Journal:  Br Med J       Date:  1964-12-26

2.  SUPPRESSION OF PLASMA RENIN ACTIVITY IN PRIMARY ALDOSTERONISM.

Authors:  J W CONN; E L COHEN; D R ROVNER
Journal:  JAMA       Date:  1964-10-19       Impact factor: 56.272

3.  Production of experimental hypertension by aldosterone.

Authors:  F GROSS; P LOUSTALOT; R MEIER
Journal:  Acta Endocrinol (Copenh)       Date:  1957-12

4.  Mechanisms of desoxycorticosterone action; relation of sodium chloride intake to fluid exchange pressor effects and survival.

Authors:  D M GREEN; D H COLEMAN; M McCABE
Journal:  Am J Physiol       Date:  1948-09-01

5.  Malignant Hypertension Produced by Treatment with Desoxycorticosterone Acetate and Sodium Chloride.

Authors:  H Selye; C E Hall; E M Rowley
Journal:  Can Med Assoc J       Date:  1943-08       Impact factor: 8.262

6.  Urinary kallikrein excretion in hypertensive man. Relationships to sodium intake and sodium-retaining steroids.

Authors:  H S Margolius; D Horwitz; J J Pisano; H R Keiser
Journal:  Circ Res       Date:  1974-12       Impact factor: 17.367

7.  Adrenergic component of renin release induced by vasodilating antihypertensive drugs in the rat.

Authors:  W A Pettinger; W B Campbell; K Keeton
Journal:  Circ Res       Date:  1973-07       Impact factor: 17.367

8.  A sensitive isotopic procedure for the assay of esterase activity: measurement of human urinary kallikrein.

Authors:  V H Beaven; J V Pierce; J J Pisano
Journal:  Clin Chim Acta       Date:  1971-03       Impact factor: 3.786

9.  Altered urinary kallikrein excretion in rats with hypertension.

Authors:  H S Margolius; R Geller; W De Jong; J J Pisano; A Sjoerdsma
Journal:  Circ Res       Date:  1972-03       Impact factor: 17.367

10.  Hypertensive action of 18-hydroxydeoxycorticosterone.

Authors:  J T Oliver; M K Birmingham; A Bartova; M P Li; T H Chan
Journal:  Science       Date:  1973-12-21       Impact factor: 47.728
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