Literature DB >> 1825188

Autoantibodies to the URNP particles: relationship to clinical diagnosis and nephritis.

M Reichlin1, W J Van Venrooij.   

Abstract

Precipitating autoantibodies to the URNP particles were used to select 80 patients, and were further characterized by immunoblotting and quantitative ELISA. These immunochemical results have been related to clinical diagnosis, the frequency of nephritis, and Raynaud's phenomenon. Autoantibodies to the 70-kD polypeptide of the U1RNP particle were present in 16 out of 19 patients with mixed connective tissue disease (MCTD) and in 27 out of 61 patients with systemic lupus erythematosus (SLE). The ratio of anti-U1RNP/Sm by ELISA and the frequency of antibody to 70-kD protein were directly related to the frequency of Raynaud's phenomenon and inversely related to the frequency of nephritis.

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Year:  1991        PMID： 1825188      PMCID： PMC1535264          DOI： 10.1111/j.1365-2249.1991.tb05629.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  22 in total

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Authors:  H H Guldner; H J Netter; C Szostecki; H J Lakomek; H Will
Journal:  J Immunol       Date:  1988-07-15       Impact factor: 5.422

3.  The use of immunoblotting and immunoprecipitation of (U) small nuclear ribonucleoproteins in the analysis of sera of patients with mixed connective tissue disease and systemic lupus erythematosus. A cross-sectional, longitudinal study.

Authors:  I Pettersson; G Wang; E I Smith; H Wigzell; E Hedfors; J Horn; G C Sharp
Journal:  Arthritis Rheum       Date:  1986-08

4.  Specific concentration of polynucleotide immune complexes in the cryoprecipitates of patients with systemic lupus erythematosus.

Authors:  J B Winfield; D Koffler; H G Kunkel
Journal:  J Clin Invest       Date:  1975-09       Impact factor: 14.808

5.  Clinical significance of anti-RNP and anti-Sm autoantibodies as determined by immunoblotting and immunoprecipitation in sera from patients with connective tissue diseases.

Authors:  B Combe; M Rucheton; H Graafland; V Lussiez; C Brunel; J Sany
Journal:  Clin Exp Immunol       Date:  1989-01       Impact factor: 4.330

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Authors:  E M Tan; A S Cohen; J F Fries; A T Masi; D J McShane; N F Rothfield; J G Schaller; N Talal; R J Winchester
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7.  Further characterization and subcellular localization of Sm and U1 ribonucleoprotein antigens.

Authors:  W J Habets; J H Berden; S O Hoch; W J Van Venrooij
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Authors:  J B Harley; E L Alexander; W B Bias; O F Fox; T T Provost; M Reichlin; H Yamagata; F C Arnett
Journal:  Arthritis Rheum       Date:  1986-02

9.  Autoantibodies against small nuclear ribonucleoprotein components.

Authors:  W J van Venrooij
Journal:  J Rheumatol Suppl       Date:  1987-06

10.  Detection of autoantibodies in a quantitative immunoassay using recombinant ribonucleoprotein antigens.

Authors:  W J Habets; M H Hoet; P T Sillekens; D J De Rooij; L B Van de Putte; W J Van Venrooij
Journal:  Clin Exp Immunol       Date:  1989-05       Impact factor: 4.330
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  14 in total

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Authors:  J B Harley; R H Scofield
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Authors:  M Tikly; S Burgin; P Mohanlal; A Bellingan; J George
Journal:  Clin Rheumatol       Date:  1996-05       Impact factor: 2.980

3.  Autoantibodies in black South Africans with systemic lupus erythematosus: spectrum and clinical associations.

Authors:  M Tikly; S Burgin; P Mohanlal; A Bellingan; J George
Journal:  Clin Rheumatol       Date:  1996-03       Impact factor: 2.980

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5.  Characterization of self-T-cell response and antigenic determinants of U1A protein with bone marrow-derived dendritic cells in NZB x NZW F1 mice.

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Review 6.  The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases.

Authors:  Nicole H Kattah; Michael G Kattah; Paul J Utz
Journal:  Immunol Rev       Date:  2010-01       Impact factor: 12.988

7.  Mapping epitopes of U1-70K autoantibodies at single-amino acid resolution.

Authors:  David James Haddon; Justin Ansel Jarrell; Vivian K Diep; Hannah E Wand; Jordan V Price; Stephanie Tangsombatvisit; Grace M Credo; Sally Mackey; Cornelia L Dekker; Emily C Baechler; Chih Long Liu; Madoo Varma; Paul J Utz
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8.  Muscle biopsy abnormalities in systemic lupus erythematosus: correlation with clinical and laboratory parameters.

Authors:  K L Lim; R Abdul-Wahab; J Lowe; R J Powell
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9.  Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis.

Authors:  P Alba; L Bento; M J Cuadrado; Y Karim; M F Tungekar; I Abbs; M A Khamashta; D D'Cruz; G R V Hughes
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10.  IgG and IgM anti-snRNP reactivity in sequentially obtained serum samples from patients with connective tissue diseases.

Authors:  U Nyman; I Lundberg; E Hedfors; M Wahren; I Pettersson
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