Debra S Heller1, Lisa Howard Rimpel, Joan H Skurnick. 1. DepartmentS of Pathology and Laboratory Medicine, UH/E158, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, P.O. Box 1709, Newark, NJ 07101, USA. hellerds@umdnj.edu
Abstract
OBJECTIVE: To evaluate the degree to which histologic chorioamnionitis, a frequent finding in placentas submitted for histopathologic evaluation, correlates with clinical indicators of infection in the mother. STUDY DESIGN: A retrospective review was performed on 52 cases with a histologic diagnosis of acute chorioamnionitis from 2,051 deliveries at University Hospital, Newark, from January 2003 to July 2003. Third-trimester placentas without histologic chorioamnionitis (n = 52) served as controls. Cases and controls were selected sequentially. Maternal medical records were reviewed for indicators of maternal infection. RESULTS: Histologic chorioamnionitis was significantly associated with the usage of antibiotics (p = 0.0095) and a higher mean white blood cell count (p = 0.018). The presence of 1 or more clinical indicators was significantly associated with the presence of histologic chorioamnionitis (p = 0.019). CONCLUSION: Histologic chorioamnionitis is a reliable indicator of infection whether or not it is clinically apparent.
OBJECTIVE: To evaluate the degree to which histologic chorioamnionitis, a frequent finding in placentas submitted for histopathologic evaluation, correlates with clinical indicators of infection in the mother. STUDY DESIGN: A retrospective review was performed on 52 cases with a histologic diagnosis of acute chorioamnionitis from 2,051 deliveries at University Hospital, Newark, from January 2003 to July 2003. Third-trimester placentas without histologic chorioamnionitis (n = 52) served as controls. Cases and controls were selected sequentially. Maternal medical records were reviewed for indicators of maternal infection. RESULTS: Histologic chorioamnionitis was significantly associated with the usage of antibiotics (p = 0.0095) and a higher mean white blood cell count (p = 0.018). The presence of 1 or more clinical indicators was significantly associated with the presence of histologic chorioamnionitis (p = 0.019). CONCLUSION: Histologic chorioamnionitis is a reliable indicator of infection whether or not it is clinically apparent.
Authors: Jennifer K Straughen; Dawn P Misra; Linda M Ernst; Adrian K Charles; Samantha VanHorn; Samiran Ghosh; Irina Buhimschi; Catalin Buhimschi; George Divine; Carolyn M Salafia Journal: BMJ Open Date: 2017-03-31 Impact factor: 2.692