| Literature DB >> 1825116 |
F J Vinick1, N A Saccomano, B K Koe, J A Nielsen, I H Williams, P F Thadeio, S Jung, M Meltz, J Johnson, L A Lebel.
Abstract
The synthesis and biological properties of a series of nicotinamide ethers are described. These compounds, structurally novel calcium-independent phosphodiesterase inhibitors, also inhibit the binding of [3H]rolipram to rat brain membranes and reverse reserpine-induced hypothermia in the mouse. Several compounds exhibited potent in vivo activity comparable to the standard agent, rolipram.Entities:
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Year: 1991 PMID： 1825116 DOI： 10.1021/jm00105a015
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446