| Literature DB >> 18250135 |
Y-J Lin1, L Wan, J J-C Sheu, C-M Huang, C-W Lin, Y-C Lan, C-H Lai, C-H Hung, Y Tsai, C-H Tsai, T-H Lin, C-P Chen, F-J Tsai.
Abstract
Interleukin-18 (IL-18) is associated with chronic inflammation, autoimmune diseases and various cancers and infectious diseases. An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma and rheumatoid arthritis. We tested a hypothesis that the IL-18 genetic polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Taiwanese SLE patients and a healthy control group. Our results indicate (1) a significantly higher A allele frequency in SLE patients (P = 0.003; OR = 1.97; 95% CI = 1.26-3.08) and (2) a significantly higher A allele frequency in SLE patients with a central nervous system disorder (P = 0.027; OR = 7.18; 95% CI = 0.95-54.28). Our results suggest that the A/C polymorphism contributes to SLE pathogenesis.Entities:
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Year: 2008 PMID： 18250135 DOI： 10.1177/0961203307086031
Source DB: PubMed Journal: Lupus ISSN： 0961-2033 Impact factor: 2.911