Activation and cytotoxicity of 5'-deoxy-5-fluorouridine in c-H-ras transformed NIH 3T3 cells.

Transformation of NIH 3T3 cells with c-H-ras has been demonstrated to result in significantly increased activation of 5'-deoxy-5-fluorouridine and significantly increased cytotoxicity in vitro as compared to non-transformed NIH 3T3. FUra cytotoxicity appeared to be increased also in vitro upon transformation; the level of significance however was beyond that of accepted significance (0.05 less than P less than 0.01). Furthermore dFUrd proved to be less active in vivo in nude mice bearing v-fos transformed NIH 3T3 cells than in nude mice bearing c-H-ras transformed cells.