| Literature DB >> 18249169 |
Michel L Tremblay1, Vincent Giguère.
Abstract
FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.Entities:
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Year: 2008 PMID： 18249169 DOI： 10.1016/j.cmet.2008.01.004
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287