| Literature DB >> 18249027 |
Marije van Beilen1, Axel T Portman, Henk A L Kiers, Ralph P Maguire, Valtteri Kaasinen, Marthe Koning, Jan Pruim, Klaus L Leenders.
Abstract
This study sought to determine the nature of the relationship between cognition and striatal dopaminergic functioning in 28 patients with advanced Parkinson's disease (PD) using fluorodopa Positron emission tomography (FDOPA-PET) and neuropsychological test scores. Mental flexibility was related to putamen activity while mental organization (executive memory and fluency) was related to caudate FDOPA uptake. Interestingly, the caudate may be more important in the mental components of executive functioning, while the putamen may be more important in the motor components of executive functioning.Entities:
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Year: 2008 PMID： 18249027 DOI： 10.1016/j.parkreldis.2007.08.011
Source DB: PubMed Journal: Parkinsonism Relat Disord ISSN： 1353-8020 Impact factor: 4.891