Literature DB >> 18248996

Design and synthesis of trans 2-(furan-2-yl)vinyl heteroaromatic iodides with antitumour activity.

Cosimo Gianluca Fortuna1, Vincenza Barresi, Giuliano Berellini, Giuseppe Musumarra.   

Abstract

A new molecular modelling approach based on physico-chemical and pharmacokinetic properties, called Volsurf plus, was used to design new heterocyclic compounds with antiproliferative activity. The synthesis and in vitro antitumour tests on a breast carcinoma cell line (MCF7) confirmed VOLSURF predicted activity values.

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Year:  2007        PMID： 18248996     DOI： 10.1016/j.bmc.2007.12.042

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  A QSPR approach to the ecotoxicity of ionic liquids (Vibrio fischeri) using VolSurf principal properties.

Authors:  Alessio Paterno'; Salvatore Scire; Giuseppe Musumarra
Journal:  Toxicol Res (Camb)       Date:  2016-04-21       Impact factor: 3.524

2.  Synthesis and antiproliferative activity of amino-substituted benzimidazo[1,2-α]quinolines as mesylate salts designed by 3D-QSAR analysis.

Authors:  Darko Vušak; Nataša Perin; Irena Martin-Kleiner; Marijeta Kralj; Grace Karminski-Zamola; Marijana Hranjec; Branimir Bertoša
Journal:  Mol Divers       Date:  2017-06-30       Impact factor: 2.943

3.  Synthesis and antitumor activity of aza-brazilan derivatives containing imidazolium salt pharmacophores.

Authors:  Mingqin Huang; Shengzu Duan; Xueqiong Ma; Bicheng Cai; Dongmei Wu; Yan Li; Liang Li; Hongbin Zhang; Xiaodong Yang
Journal:  Medchemcomm       Date:  2019-05-10       Impact factor: 3.597

4.  Eco-friendly synthesis, in vitro anti-proliferative evaluation, and 3D-QSAR analysis of a novel series of monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates.

Authors:  Livio Racané; Lucija Ptiček; Mirela Sedić; Petra Grbčić; Sandra Kraljević Pavelić; Branimir Bertoša; Irena Sović; Grace Karminski-Zamola
Journal:  Mol Divers       Date:  2018-04-17       Impact factor: 2.943

5.  Novel Amino-Pyridine Functionalized Chitosan Quaternary Ammonium Derivatives: Design, Synthesis, and Antioxidant Activity.

Authors:  Qing Li; Caili Zhang; Wenqiang Tan; Guodong Gu; Zhanyong Guo
Journal:  Molecules       Date:  2017-01-18       Impact factor: 4.411

6.  Determination of Structural Requirements of N-Substituted Tetrahydro-β-Carboline Imidazolium Salt Derivatives Using in Silico Approaches for Designing MEK-1 Inhibitors.

Authors:  Jingwei Liang; Mingyang Wang; Xinyang Li; Xin He; Chong Cao; Fanhao Meng
Journal:  Molecules       Date:  2017-06-19       Impact factor: 4.411

7.  Synthesis and biological study of acridine-based imidazolium salts.

Authors:  Olla Sharhan; Thorsten Heidelberg; Najiahah Mohd Hashim; Abbas Abdulameer Salman; Hapipah Mohd Ali; Soher Nagi Jayash
Journal:  RSC Adv       Date:  2018-11-20       Impact factor: 4.036

8.  Synthesis and antitumor activity of novel N-substituted carbazole imidazolium salt derivatives.

Authors:  Lan-Xiang Liu; Xue-Quan Wang; Bei Zhou; Li-Juan Yang; Yan Li; Hong-Bin Zhang; Xiao-Dong Yang
Journal:  Sci Rep       Date:  2015-08-19       Impact factor: 4.379

9.  Reversible photoswitching of the DNA-binding properties of styrylquinolizinium derivatives through photochromic [2 + 2] cycloaddition and cycloreversion.

Authors:  Sarah Kölsch; Heiko Ihmels; Jochen Mattay; Norbert Sewald; Brian O Patrick
Journal:  Beilstein J Org Chem       Date:  2020-01-23       Impact factor: 2.883
  9 in total

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