Literature DB >> 18248912

5-HT inhibits synaptic transmission in rat subthalamic nucleus neurons in vitro.

K-Z Shen1, S W Johnson.   

Abstract

The subthalamic nucleus (STN) plays a pivotal role in normal and abnormal motor function. We used patch pipettes to study effects of 5-HT on synaptic currents evoked in STN neurons by focal electrical stimulation of rat brain slices. 5-HT (10 microM) reduced glutamate-mediated excitatory postsynaptic currents (EPSCs) by 35+/-4%. However, a much higher concentration of 5-HT (100 microM) was required to inhibit GABA-mediated inhibitory postsynaptic currents (IPSCs) to a comparable extent. Concentration-response curves showed that the 5-HT inhibitory concentration 50% (IC50) for inhibition of IPSCs (20.2 microM) was more than fivefold greater than the IC50 for inhibition of EPSCs (3.4 microM). The 5-HT-induced reductions in EPSCs and IPSCs were accompanied by increases in paired-pulse ratios, indicating that 5-HT acts presynaptically to inhibit synaptic transmission. The 5-HT1B receptor antagonist NAS-181 significantly antagonized 5-HT-induced inhibitions of EPSCs and IPSCs. These studies show that 5-HT inhibits synaptic transmission in the STN by activating presynaptic 5-HT1B receptors.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18248912      PMCID： PMC2279230          DOI： 10.1016/j.neuroscience.2007.12.001

Source DB:  PubMed          Journal:  Neuroscience        ISSN： 0306-4522            Impact factor:   3.590


  33 in total

1.  Cellular and subcellular localization of 5-hydroxytryptamine1B receptors in the rat central nervous system: immunocytochemical, autoradiographic and lesion studies.

Authors:  Y Sari; M C Miquel; M J Brisorgueil; G Ruiz; E Doucet; M Hamon; D Vergé
Journal:  Neuroscience       Date:  1999       Impact factor: 3.590

Review 2.  The functional anatomy of disorders of the basal ganglia.

Authors:  R L Albin; A B Young; J B Penney
Journal:  Trends Neurosci       Date:  1995-02       Impact factor: 13.837

3.  Lesion study of the distribution of serotonin 5-HT4 receptors in rat basal ganglia and hippocampus.

Authors:  V Compan; A Daszuta; P Salin; M Sebben; J Bockaert; A Dumuis
Journal:  Eur J Neurosci       Date:  1996-12       Impact factor: 3.386

4.  SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors.

Authors:  G W Price; M J Burton; L J Collin; M Duckworth; L Gaster; M Göthert; B J Jones; C Roberts; J M Watson; D N Middlemiss
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1997-09       Impact factor: 3.000

5.  Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro.

Authors:  I M Stanford; M G Lacey
Journal:  J Neurosci       Date:  1996-12-01       Impact factor: 6.167

6.  Presynaptic inhibition of glutamatergic synaptic transmission to rat motoneurons by serotonin.

Authors:  J H Singer; M C Bellingham; A J Berger
Journal:  J Neurophysiol       Date:  1996-08       Impact factor: 2.714

7.  Effect of 5-HT1B/D receptor agonist and antagonist administration on motor function in haloperidol and MPTP-treated common marmosets.

Authors:  Michael J Jackson; Ghassan Al-Barghouthy; Ronald K B Pearce; Lance Smith; James J Hagan; Peter Jenner
Journal:  Pharmacol Biochem Behav       Date:  2004-11       Impact factor: 3.533

8.  Regulation of EPSPs by the synaptic activation of GABAB autoreceptors in rat hippocampus.

Authors:  C H Davies; G L Collingridge
Journal:  J Physiol       Date:  1996-10-15       Impact factor: 5.182

9.  Treatment of tremor in Parkinson's disease by subthalamic nucleus stimulation.

Authors:  P Krack; A Benazzouz; P Pollak; P Limousin; B Piallat; D Hoffmann; J Xie; A L Benabid
Journal:  Mov Disord       Date:  1998-11       Impact factor: 10.338

10.  Serotonin inhibits synaptic glutamate currents in rat nucleus accumbens neurons via presynaptic 5-HT1B receptors.

Authors:  M Muramatsu; M D Lapiz; E Tanaka; J Grenhoff
Journal:  Eur J Neurosci       Date:  1998-07       Impact factor: 3.386
View more
  7 in total

Review 1.  Multiple controls exerted by 5-HT2C receptors upon basal ganglia function: from physiology to pathophysiology.

Authors:  P De Deurwaerdère; M Lagière; M Bosc; S Navailles
Journal:  Exp Brain Res       Date:  2013-04-25       Impact factor: 1.972

2.  Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.

Authors:  J-D Guo; D G Rainnie
Journal:  Neuroscience       Date:  2009-12-03       Impact factor: 3.590

3.  Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection.

Authors:  Shengyuan Ding; Li Li; Fu-Ming Zhou
Journal:  J Neurosci       Date:  2013-03-13       Impact factor: 6.167

Review 4.  Interaction between the 5-HT system and the basal ganglia: functional implication and therapeutic perspective in Parkinson's disease.

Authors:  Cristina Miguelez; Teresa Morera-Herreras; Maria Torrecilla; Jose A Ruiz-Ortega; Luisa Ugedo
Journal:  Front Neural Circuits       Date:  2014-03-17       Impact factor: 3.492

5.  Tai Chi postural training for dyskinesia rehabilitation: a study protocol for a randomised controlled trial in convalescent ischaemic stroke patients.

Authors:  Chengyang Jing; Kuangshi Li; Zongheng Li; Yiting Sun; Jiabao Wu; Yingjie Li; Yuyue Li; Li Zhou; Zhe Zhang; Mingzhi Zhao; Yong Zhang
Journal:  BMJ Open       Date:  2021-05-18       Impact factor: 2.692

6.  Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey.

Authors:  Hyo-Jin Jeong; David Chenu; Emma E Johnson; Mark Connor; Christopher W Vaughan
Journal:  Mol Pain       Date:  2008-11-11       Impact factor: 3.395

Review 7.  The 5-HT1B receptor - a potential target for antidepressant treatment.

Authors:  Mikael Tiger; Katarina Varnäs; Yoshiro Okubo; Johan Lundberg
Journal:  Psychopharmacology (Berl)       Date:  2018-03-15       Impact factor: 4.530
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.