| Literature DB >> 18248798 |
Abstract
Semi-synthetic penicillins and cephalosporins both derive from their respective chemical nuclei, 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA). Work leading to their isolation was being carried out in parallel, but following very different pathways, during the last half of the 1950s. The development of 6-APA was reviewed recently in this journal, and in the present article I take a closer look at early work on 'penicillin amidase' and revisit the steps that led to 7-ACA.Entities:
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Year: 2008 PMID： 18248798 DOI： 10.1016/j.ijantimicag.2007.11.010
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283