| Literature DB >> 18248757 |
Ivan P Nascimento1, Waldely O Dias, Wagner Quintilio, Ana P Christ, Josefina F Moraes, Mary D C Vancetto, Gabriela Ribeiro-Dos-Santos, Isaias Raw, Luciana C C Leite.
Abstract
The currently used pertussis vaccines are highly efficacious; however, neonates are susceptible to whooping cough up to the sixth month. In agreement, DTP-immunized neonate mice were not protected against intracerebral challenge with Bordetella pertussis. Neonate mice immunized with either DTP or a recombinant-BCG strain expressing the genetically detoxified S1 subunit of pertussis toxin do not show a humoral immune response against PT. On the other hand, rBCG-Pertussis induces higher PT-specific IFN-gamma production and an increase in both IFN-gamma(+) and TNF-alpha(+)-CD4(+)-T cells than the whole cell pertussis vaccine and confers protection against a lethal intracerebral challenge with B. pertussis.Entities:
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Year: 2007 PMID： 18248757 DOI： 10.1016/j.micinf.2007.10.010
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700