Literature DB >> 18248522

Can the risk of gadolinium be extrapolated to lanthanum?

Marc E De Broe1.   

Abstract

The recent recognition of gadolinium (Gd) administration as a cause of nephrogenic systemic fibrosis (NSF) is a growing concern. The similarity of Gd and lanthanum (La), based on their place in the table of Mendeljev, has led to assumptions that the NSF risk of Gd in patients with kidney disease can de extrapolated to La. However, Gd and La, two trivalent cations, differ substantially in their metabolism, pharmacokinetics, and most importantly in their clinical use and toxicity. Thus, it is extremely unlikely that La can cause NSF.

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Year:  2008        PMID: 18248522     DOI: 10.1111/j.1525-139X.2007.00416.x

Source DB:  PubMed          Journal:  Semin Dial        ISSN: 0894-0959            Impact factor:   3.455


  2 in total

1.  Gadolinium-promoted cell cycle progression with enhanced S-phase entry via activation of both ERK and PI3K signaling pathways in NIH 3T3 cells.

Authors:  Li-Juan Fu; Jin-Xia Li; Xiao-Gai Yang; Kui Wang
Journal:  J Biol Inorg Chem       Date:  2008-10-25       Impact factor: 3.358

Review 2.  Clinical pharmacokinetics of the phosphate binder lanthanum carbonate.

Authors:  Stephen J P Damment; Michael Pennick
Journal:  Clin Pharmacokinet       Date:  2008       Impact factor: 6.447

  2 in total

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