| Literature DB >> 18247573 |
E M Kithsiri Wijeratne1, Priyani A Paranagama, Marilyn T Marron, Malkanthi K Gunatilaka, A Elizabeth Arnold, A A Leslie Gunatilaka.
Abstract
Five new metabolites, (+)-(5 S,10 S)-4'-hydroxymethylcyclozonarone ( 1), 3-ketotauranin ( 3), 3alpha-hydroxytauranin ( 4), 12-hydroxytauranin ( 5), and phyllospinarone ( 6), together with tauranin ( 2), were isolated from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis. The structures of the new compounds were determined on the basis of their 1D and 2D NMR spectroscopic data and chemical interconversions. All compounds were evaluated for inhibition of cell proliferation in a panel of five cancer cell lines, and only tauranin ( 2) showed activity. When tested in a flow cytometry-based assay, tauranin induced apoptosis in PC-3M and NIH 3T3 cell lines.Entities:
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Year: 2008 PMID： 18247573 DOI： 10.1021/np070600c
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050