Literature DB >> 18247365

Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair.

Carmen E Macsai1, Bruce K Foster, Cory J Xian.   

Abstract

Wnt signalling has an essential role in regulating bone formation and remodelling during embryonic development and throughout postnatal and adult life. Specifically, Wnt signalling regulates bone formation by controlling embryonic cartilage development and postnatal chondrogenesis, osteoblastogenesis, osteoclastogenesis, endochondral bone formation, and bone remodelling. Abnormalities in the function of Wnt genes give rise to or contribute to the development of several pathological bone conditions, including abnormal bone mass, osteosarcomas and bone loss in multiple myeloma. Furthermore, Wnt signalling is activated during bone fracture repair and plays a crucial role in regulating bone regeneration. (c) 2008 Wiley-Liss, Inc.

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Year:  2008        PMID： 18247365     DOI： 10.1002/jcp.21342

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  65 in total

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3.  Opposite spectrum of activity of canonical Wnt signaling in the osteogenic context of undifferentiated and differentiated mesenchymal cells: implications for tissue engineering.

Authors:  Natalina Quarto; Björn Behr; Michael T Longaker
Journal:  Tissue Eng Part A       Date:  2010-10       Impact factor: 3.845

Review 4.  Regulation of Long Bone Growth in Vertebrates; It Is Time to Catch Up.

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Journal:  Endocr Rev       Date:  2015-10-20       Impact factor: 19.871

Review 5.  Osteoblast migration in vertebrate bone.

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6.  miR-29 suppression of osteonectin in osteoblasts: regulation during differentiation and by canonical Wnt signaling.

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Journal:  J Cell Biochem       Date:  2009-09-01       Impact factor: 4.429

Review 7.  Osteogenic differentiation of amniotic fluid mesenchymal stromal cells and their bone regeneration potential.

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Journal:  World J Stem Cells       Date:  2015-05-26       Impact factor: 5.326

8.  Structural maintenance of chromosome complexes and bone development: the beginning of a wonderful relationship?

Authors:  Miri Cohen-Zinder; Miri Zinder-Cohen; David Karasik; Itay Onn
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Review 9.  Cilia involvement in patterning and maintenance of the skeleton.

Authors:  Courtney J Haycraft; Rosa Serra
Journal:  Curr Top Dev Biol       Date:  2008       Impact factor: 4.897

10.  Regulatory pathways associated with bone loss and bone marrow adiposity caused by aging, chemotherapy, glucocorticoid therapy and radiotherapy.

Authors:  Kristen R Georgiou; Susanta K Hui; Cory J Xian
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