Literature DB >> 18247160

Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes.

Yi-Sheng Yang1, Xiao-Ying Li, Jie Hong, Wei-Qiong Gu, Yi-Fei Zhang, Jun Yang, Huai-Dong Song, Jia-Lun Chen, Guang Ning.   

Abstract

In order to characterize the potential causative effects of interleukin-18 (IL-18) on insulin resistance, we measured glucose uptake in 3T3-L1 adipocytes treated with mouse recombinant IL-18. IL-18 surprisingly enhanced, rather than reduced insulin-mediated glucose uptake in adipocytes. Moreover IL-18 could counteract the glucose uptake suppression caused by tumor necrosis factor alpha in 3T3-L1 adipocytes. The mechanism dissection showed that the IL-18 upregulated phosphorylated Akt and downregulated phosphorylated P38 MAPK. These findings indicated that the elevated serum IL-18 levels in obesity and diabetes might be a compensatory response to insulin resistance.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18247160     DOI： 10.1007/s12020-008-9048-z

Source DB:  PubMed          Journal:  Endocrine        ISSN： 1355-008X            Impact factor:   3.633


  29 in total

1.  Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans.

Authors:  Christian P Fischer; Lisbeth B Perstrup; Annika Berntsen; Peter Eskildsen; Bente K Pedersen
Journal:  Clin Immunol       Date:  2005-08-19       Impact factor: 3.969

2.  Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial.

Authors:  Katherine Esposito; Alessandro Pontillo; Carmen Di Palo; Giovanni Giugliano; Mariangela Masella; Raffaele Marfella; Dario Giugliano
Journal:  JAMA       Date:  2003-04-09       Impact factor: 56.272

3.  The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFalpha in human adipocytes.

Authors:  I Stuart Wood; Bohan Wang; John R Jenkins; Paul Trayhurn
Journal:  Biochem Biophys Res Commun       Date:  2005-09-21       Impact factor: 3.575

4.  Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake.

Authors:  L M Fletcher; G I Welsh; P B Oatey; J M Tavaré
Journal:  Biochem J       Date:  2000-12-01       Impact factor: 3.857

Review 5.  Interleukin-18 and the pathogenesis of inflammatory diseases.

Authors:  Charles A Dinarello
Journal:  Semin Nephrol       Date:  2007-01       Impact factor: 5.299

6.  Adipose tissue interleukin-18 mRNA and plasma interleukin-18: effect of obesity and exercise.

Authors:  Lotte Leick; Birgitte Lindegaard; Dorthe Stensvold; Peter Plomgaard; Bengt Saltin; Henriette Pilegaard
Journal:  Obesity (Silver Spring)       Date:  2007-02       Impact factor: 5.002

7.  Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes.

Authors:  Christian J Carlson; Cristina M Rondinone
Journal:  Metabolism       Date:  2005-07       Impact factor: 8.694

8.  c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes.

Authors:  Kun-yong Kim; Jae Kwang Kim; Jun Ho Jeon; Suk Ran Yoon; Inpyo Choi; Young Yang
Journal:  Biochem Biophys Res Commun       Date:  2005-02-11       Impact factor: 3.575

9.  Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

Authors:  B W Winston; C A Lange-Carter; A M Gardner; G L Johnson; D W Riches
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

10.  Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity.

Authors:  Héctor F Escobar-Morreale; José I Botella-Carretero; Gemma Villuendas; José Sancho; José L San Millán
Journal:  J Clin Endocrinol Metab       Date:  2004-02       Impact factor: 5.958
View more
  5 in total

Review 1.  IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance.

Authors:  Dov B Ballak; Rinke Stienstra; Cees J Tack; Charles A Dinarello; Janna A van Diepen
Journal:  Cytokine       Date:  2015-07-17       Impact factor: 3.861

2.  Endogenous interleukin 18 suppresses hyperglycemia and hyperinsulinemia during the acute phase of endotoxemia in mice.

Authors:  Hayato Yamashita; Michiko Aoyama-Ishikawa; Miki Takahara; Chisato Yamauchi; Taketo Inoue; Makoto Miyoshi; Noriaki Maeshige; Makoto Usami; Atsunori Nakao; Joji Kotani
Journal:  Surg Infect (Larchmt)       Date:  2015-02-04       Impact factor: 2.150

Review 3.  Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance.

Authors:  Layla Al-Mansoori; Hend Al-Jaber; Mohammad Shoaib Prince; Mohamed A Elrayess
Journal:  Inflammation       Date:  2021-09-18       Impact factor: 4.092

4.  Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes.

Authors:  Dan Gao; Mohamed Madi; Cherlyn Ding; Matthew Fok; Thomas Steele; Christopher Ford; Leif Hunter; Chen Bing
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-06-10       Impact factor: 4.310

5.  The effect of chronic candesartan therapy on the metabolic profile and renal tissue cytokine levels in the obese Zucker rat.

Authors:  Carolyn M Ecelbarger; Arjun Rash; Rajesh K Sinha; Swasti Tiwari
Journal:  Mediators Inflamm       Date:  2010-05-17       Impact factor: 4.711
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.