BACKGROUND AND PURPOSE: Venous thromboembolism (VTE) is well-recognized complication of cancer; however its pathogenesis is not entirely established. Protein Z (PZ) is a member of the coagulation cascade. We aimed to investigate whether intron F G79A polymorphism of PZ gene is associated with risk of VTE in cancer patients. MATERIALS AND METHODS: The study consisted of 55 cancer patients who developed thrombosis (group 1) and 115 cancer patients without VTE (group 2). Intron F G79A of PZ gene, factor V Leiden (FVL) and prothrombin (PT) G20210A polymorphisms were determined by the method of polymerase chain reaction-based DNA analysis. RESULTS: The prevalence of FVL was significantly greater in group 1 compared with group 2 (27.3% vs. 3.5%, P < 0.0001). No differences were seen in genotype and allele frequencies of PZ gene between two groups (P > 0.05). When the analysis was also made after excluding FVL positive patients, the same insignificant result was found. CONCLUSION: Intron F G79A polymorphism of PZ gene does not contribute to meaningful diagnostic investigation of thrombophilia in cancer patients.
BACKGROUND AND PURPOSE:Venous thromboembolism (VTE) is well-recognized complication of cancer; however its pathogenesis is not entirely established. Protein Z (PZ) is a member of the coagulation cascade. We aimed to investigate whether intron F G79A polymorphism of PZ gene is associated with risk of VTE in cancerpatients. MATERIALS AND METHODS: The study consisted of 55 cancerpatients who developed thrombosis (group 1) and 115 cancerpatients without VTE (group 2). Intron F G79A of PZ gene, factor V Leiden (FVL) and prothrombin (PT) G20210A polymorphisms were determined by the method of polymerase chain reaction-based DNA analysis. RESULTS: The prevalence of FVL was significantly greater in group 1 compared with group 2 (27.3% vs. 3.5%, P < 0.0001). No differences were seen in genotype and allele frequencies of PZ gene between two groups (P > 0.05). When the analysis was also made after excluding FVL positive patients, the same insignificant result was found. CONCLUSION: Intron F G79A polymorphism of PZ gene does not contribute to meaningful diagnostic investigation of thrombophilia in cancerpatients.
Authors: C Lichy; S Kropp; T Dong-Si; J Genius; T Dolan; T Hampe; F Stoll; K Reuner; C Grond-Ginsbach; A Grau Journal: Stroke Date: 2003-12-11 Impact factor: 7.914
Authors: R Santacroce; M Sarno; F Cappucci; F Sessa; D Colaizzo; V Brancaccio; E Grandone; M Margaglione Journal: J Thromb Haemost Date: 2006-08-25 Impact factor: 5.824
Authors: Ali Al-Shanqeeti; Astrid van Hylckama Vlieg; Erik Berntorp; Frits R Rosendaal; George J Broze Journal: Thromb Haemost Date: 2005-03 Impact factor: 5.249
Authors: Ewa Sierko; Marek Z Wojtukiewicz; Lech Zimnoch; Piotr Tokajuk; Krystyna Ostrowska-Cichocka; Walter Kisiel Journal: Ann Hematol Date: 2013-10-26 Impact factor: 3.673