| Literature DB >> 18245656 |
Eduard J van Beers, Max Nieuwdorp, Ashley J Duits, Ludo M Evers, John-John B Schnog, Bart J Biemond.
Abstract
The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbSbeta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbSbeta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1 x 10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.Entities:
Mesh：
Year: 2008 PMID： 18245656 DOI： 10.3324/haematol.12027
Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941