| Literature DB >> 18245344 |
Pierre Faubet1, Oscar E Gaggiotti.
Abstract
We present a new multilocus genotype method that makes inferences about recent immigration rates and identifies the environmental factors that are more likely to explain observed gene flow patterns. It also estimates population-specific inbreeding coefficients, allele frequencies, and local population F(ST)'s and performs individual assignments. We generate synthetic data sets to determine the region of the parameter space where our method is and is not able to provide accurate estimates. Our simulation study indicates that reliable results can be obtained when the global level of genetic differentiation (F(ST)) is >1%, the number of loci is only 10, and sample sizes are of the order of 50 individuals per population. We illustrate our method by applying it to Pakistani human data, considering altitude and geographic distance as explanatory factors. Our results suggest that altitude explains better the genetic data than geographic distance. Additionally, they show that southern low-altitude populations have higher migration rates than northern high-altitude ones.Entities:
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Year: 2008 PMID: 18245344 PMCID: PMC2278086 DOI: 10.1534/genetics.107.082560
Source DB: PubMed Journal: Genetics ISSN: 0016-6731 Impact factor: 4.562