C C A Sng1, A Jap, Y H Chan, S-P Chee. 1. Department of Ophthalmology, National University Hospital, 10A Gallop Road, Singapore 258975. chelvin@gmail.com
Abstract
AIM: To identify risk factors for Klebsiella endophthalmitis in patients with Klebsiella sepsis. METHODS: This is a retrospective case-control study. The study population consisted of all patients with positive blood cultures for Klebsiella, admitted to Changi General Hospital (Singapore) from August 2004 to July 2005. The cases were patients who developed Klebsiella endophthalmitis, and the controls were those who did not. The potential risk factors analysed included age, sex, race and total white cell count at presentation, maximum temperature response, co-morbid pathologies, presence of severe infection, site of primary infection, antibiotic sensitivity of the bacterial strain, and systemic antibiotics treatment regimen. RESULTS: 133 consecutive patients with Klebsiella bacteraemia confirmed by blood culture were included. Five (3.8%) developed endophthalmitis. Klebsiella endophthalmitis was significantly associated with liver abscess as the primary site of infection (p<0.001) and disseminated intravascular coagulation (p = 0.010) on both univariate and multivariate analysis. Diabetes mellitus and other co-morbid pathologies, race and maximum temperature response were not risk factors for the occurrence of endophthalmitis. CONCLUSIONS: Liver abscess and disseminated intravascular coagulation are risk factors for endogenous endophthalmitis in patients with Klebsiella sepsis.
AIM: To identify risk factors for Klebsiella endophthalmitis in patients with Klebsiella sepsis. METHODS: This is a retrospective case-control study. The study population consisted of all patients with positive blood cultures for Klebsiella, admitted to Changi General Hospital (Singapore) from August 2004 to July 2005. The cases were patients who developed Klebsiella endophthalmitis, and the controls were those who did not. The potential risk factors analysed included age, sex, race and total white cell count at presentation, maximum temperature response, co-morbid pathologies, presence of severe infection, site of primary infection, antibiotic sensitivity of the bacterial strain, and systemic antibiotics treatment regimen. RESULTS: 133 consecutive patients with Klebsiella bacteraemia confirmed by blood culture were included. Five (3.8%) developed endophthalmitis. Klebsiella endophthalmitis was significantly associated with liver abscess as the primary site of infection (p<0.001) and disseminated intravascular coagulation (p = 0.010) on both univariate and multivariate analysis. Diabetes mellitus and other co-morbid pathologies, race and maximum temperature response were not risk factors for the occurrence of endophthalmitis. CONCLUSIONS:Liver abscess and disseminated intravascular coagulation are risk factors for endogenous endophthalmitis in patients with Klebsiella sepsis.
Authors: Chun Yue Mak; Mary Ho; Lawrence Pui-Leung Iu; Helena Pui-Yee Sin; Li Jia Chen; Grace Lui; Marten Erik Brelen; Alvin Lerrmann Young Journal: Int J Ophthalmol Date: 2020-12-18 Impact factor: 1.779
Authors: P P Connell; E C O'Neill; D Fabinyi; F M A Islam; R Buttery; M McCombe; R W Essex; E Roufail; B Clark; D Chiu; W Campbell; P Allen Journal: Eye (Lond) Date: 2010-10-22 Impact factor: 3.775
Authors: In Hyung Park; Chung Hwan Jun; Jin Woo Wi; Seon Young Park; Wan Sik Lee; Sook In Jung; Chang Hwan Park; Young Eun Joo; Hyun Soo Kim; Sung Kyu Choi; Jong Sun Rew Journal: Korean J Intern Med Date: 2015-06-29 Impact factor: 2.884