Literature DB >> 18245122

Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition.

Faiez Zannad1, Wendy Gattis Stough, Bertram Pitt, John G F Cleland, Kirkwood F Adams, Nancy L Geller, Christian Torp-Pedersen, Bridget-Anne Kirwan, Ferenc Follath.   

Abstract

Specific criteria have been established to define the occurrence of myocardial infarction (MI) and stroke in cardiovascular clinical trials, but there is not a consistent definition for heart failure. Heart failure events appear to occur at a rate that is similar to stroke and MI in trials of hypertension, hyperlipidaemia, diabetes, and coronary heart disease, yet a consistent approach to defining heart failure events has not yet been realized. The wide range of definitions used in clinical trials makes it difficult to interpret new data in the context of existing literature. This inconsistency has led to challenges in determining the incidence of heart failure in cardiovascular studies and the effects of interventions on these endpoints. This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue.

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Year:  2008        PMID： 18245122     DOI： 10.1093/eurheartj/ehm603

Source DB:  PubMed          Journal:  Eur Heart J        ISSN： 0195-668X            Impact factor:   29.983


  14 in total

1.  Classification of heart failure in the atherosclerosis risk in communities (ARIC) study: a comparison of diagnostic criteria.

Authors:  Wayne D Rosamond; Patricia P Chang; Chris Baggett; Anna Johnson; Alain G Bertoni; Eyal Shahar; Anita Deswal; Gerardo Heiss; Lloyd E Chambless
Journal:  Circ Heart Fail       Date:  2012-01-23       Impact factor: 8.790

2.  Use of bevacizumab as a first-line treatment for metastatic breast cancer.

Authors:  L Manso; F Moreno; R Márquez; B Castelo; A Arcediano; M Arroyo; A I Ballesteros; I Calvo; M J Echarri; S Enrech; A Gómez; R González Del Val; E López-Miranda; M Martín-Angulo; N Martínez-Jañez; C Olier; P Zamora
Journal:  Curr Oncol       Date:  2015-04       Impact factor: 3.677

3.  Classification of acute decompensated heart failure: an automated algorithm compared with a physician reviewer panel: the Atherosclerosis Risk in Communities study.

Authors:  Laura R Loehr; Sunil K Agarwal; Chris Baggett; Lisa M Wruck; Patricia P Chang; Scott D Solomon; Eyal Shahar; Hanyu Ni; Wayne D Rosamond; Gerardo Heiss
Journal:  Circ Heart Fail       Date:  2013-05-06       Impact factor: 8.790

4.  Cardiac neuronal imaging with ¹²³I-meta-iodobenzylguanidine in heart failure: implications of endpoint selection and quantitative analysis on clinical decisions.

Authors:  Mario Petretta; Teresa Pellegrino; Alberto Cuocolo
Journal:  Eur J Nucl Med Mol Imaging       Date:  2014-06-11       Impact factor: 9.236

5.  Heart failure event definitions in drug trials in patients with type 2 diabetes.

Authors:  Abhinav Sharma; Deepak L Bhatt; Gonzalo Calvo; Nancy J Brown; Faiez Zannad; Robert J Mentz
Journal:  Lancet Diabetes Endocrinol       Date:  2016-04       Impact factor: 32.069

Review 6.  Are all outcomes in chronic heart failure rated equally? An argument for a patient-centred approach to outcome assessment.

Authors:  Sungwon Chang; Phillip J Newton; Sally Inglis; Tim Luckett; Henry Krum; Peter Macdonald; Patricia M Davidson
Journal:  Heart Fail Rev       Date:  2014-03       Impact factor: 4.214

7.  Comparing CMR Mapping Methods and Myocardial Patterns Toward Heart Failure Outcomes in Nonischemic Dilated Cardiomyopathy.

Authors:  Tomas Vita; Christoph Gräni; Siddique A Abbasi; Tomas G Neilan; Ethan Rowin; Kyoichi Kaneko; Otavio Coelho-Filho; Eri Watanabe; Francois-Pierre Mongeon; Hoshang Farhad; Carlos Henrique Rassi; Yuna L Choi; Kathleen Cheng; Michael M Givertz; Ron Blankstein; Michael Steigner; Ayaz Aghayev; Michael Jerosch-Herold; Raymond Y Kwong
Journal:  JACC Cardiovasc Imaging       Date:  2018-11-15

8.  Risk of Death and Heart Failure among Patients with Type 2 Diabetes Treated by Metformin and Nonmetformin Monotherapy: A Real-World Study.

Authors:  Siyao He; Xin Qian; Yanyan Chen; Xiaoxia Shen; Bo Zhang; Xiaoping Chen; Xiangjin Xu; Guangwei Li
Journal:  J Diabetes Res       Date:  2021-06-10       Impact factor: 4.011

9.  Primary prevention of heart failure.

Authors:  Javed Butler
Journal:  ISRN Cardiol       Date:  2012-08-16

10.  Trends in quality of care among patients with incident heart failure in Denmark 2003-2010: a nationwide cohort study.

Authors:  Anne Nakano; Søren Paaske Johnsen; Birgitte Lidegaard Frederiksen; Marie Louise Svendsen; Carsten Agger; Inge Schjødt; Kenneth Egstrup
Journal:  BMC Health Serv Res       Date:  2013-10-05       Impact factor: 2.655
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