Literature DB >> 18245019

Metabotropic glutamate receptor agonists for schizophrenia.

Paul J Harrison.   

Abstract

A drug acting at metabotropic glutamate receptors has recently been reported to be an effective antipsychotic, breaking the rule that only dopamine receptor-blocking drugs have this property. The finding complements accumulating evidence that glutamatergic abnormalities are important in the pathophysiology of schizophrenia.

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Year:  2008        PMID： 18245019     DOI： 10.1192/bjp.bp.107.045088

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


  9 in total

1.  Blinding in clozapine trials: a problem and a potential solution.

Authors:  Tamar Wohlfarth; Don Linszen; Wim Van Den Brink
Journal:  Int J Methods Psychiatr Res       Date:  2009-09       Impact factor: 4.035

2.  Group II metabotropic glutamate receptor agonist ameliorates MK801-induced dysfunction of NMDA receptors via the Akt/GSK-3β pathway in adult rat prefrontal cortex.

Authors:  Dong Xi; Yan-Chun Li; Melissa A Snyder; Ruby Y Gao; Alicia E Adelman; Wentong Zhang; Jed S Shumsky; Wen-Jun Gao
Journal:  Neuropsychopharmacology       Date:  2011-02-16       Impact factor: 7.853

3.  Pharmacologic treatment of first-episode schizophrenia: a review of the literature.

Authors:  Shibu P Thomas; Harpal Sing Nandhra; Swaran P Singh
Journal:  Prim Care Companion CNS Disord       Date:  2012-01-05

4.  The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.

Authors:  Michele Bellesi; Fiorenzo Conti
Journal:  Neuropsychopharmacology       Date:  2010-01-13       Impact factor: 7.853

Review 5.  Recent advances in treating cognitive impairment in schizophrenia.

Authors:  Cherrie Galletly
Journal:  Psychopharmacology (Berl)       Date:  2008-09-03       Impact factor: 4.530

6.  Magnetic resonance imaging of glutamate.

Authors:  Kejia Cai; Mohammad Haris; Anup Singh; Feliks Kogan; Joel H Greenberg; Hari Hariharan; John A Detre; Ravinder Reddy
Journal:  Nat Med       Date:  2012-01-22       Impact factor: 53.440

Review 7.  Group II Metabotropic Glutamate Receptors as Targets for Novel Antipsychotic Drugs.

Authors:  Carolina Muguruza; J Javier Meana; Luis F Callado
Journal:  Front Pharmacol       Date:  2016-05-20       Impact factor: 5.810

8.  Altered hippocampal expression of glutamate receptors and transporters in GRM2 and GRM3 knockout mice.

Authors:  Louisa Lyon; James N C Kew; Corrado Corti; Paul J Harrison; Philip W J Burnet
Journal:  Synapse       Date:  2008-11       Impact factor: 2.562

9.  Pomaglumetad Methionil (LY2140023 Monohydrate) and Aripiprazole in Patients with Schizophrenia: A Phase 3, Multicenter, Double-Blind Comparison.

Authors:  David H Adams; Lu Zhang; Brian A Millen; Bruce J Kinon; Juan-Carlos Gomez
Journal:  Schizophr Res Treatment       Date:  2014-03-19
  9 in total

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