Literature DB >> 18243821

Quantification of nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry.

Teresa R Gray1, Diaa M Shakleya, Marilyn A Huestis.   

Abstract

There are no analytical methods that simultaneously quantify nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine and norcotinine in human meconium. Such a method could improve identification of in utero tobacco exposure, determine if maternal dose-meconium concentration relationships exist, and whether nicotine meconium concentrations predict neonatal outcomes. The first liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry method for simultaneous quantification of these analytes in meconium was developed and validated. Specimen preparation included homogenization, enzyme hydrolysis and solid phase extraction. The linear range was 1.25 or 5-500ng/g. Method applicability was evaluated with meconium collected from an in utero tobacco exposed infant.

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Year:  2008        PMID： 18243821      PMCID： PMC2775062          DOI： 10.1016/j.jchromb.2008.01.001

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  23 in total

1.  A simple high performance liquid chromatographic method for the quantification of total cotinine, total 3'-hydroxycotinine and caffeine in the plasma of smokers.

Authors:  O A Ghosheh; D Browne; T Rogers; J de Leon; L P Dwoskin; P A Crooks
Journal:  J Pharm Biomed Anal       Date:  2000-08-15       Impact factor: 3.935

2.  Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS.

Authors:  B K Matuszewski; M L Constanzer; C M Chavez-Eng
Journal:  Anal Chem       Date:  2003-07-01       Impact factor: 6.986

3.  Evidence for urinary excretion of glucuronide conjugates of nicotine, cotinine, and trans-3'-hydroxycotinine in smokers.

Authors:  G D Byrd; K M Chang; J M Greene; J D deBethizy
Journal:  Drug Metab Dispos       Date:  1992 Mar-Apr       Impact factor: 3.922

4.  Meconium analysis to assess fetal exposure to nicotine by active and passive maternal smoking.

Authors:  E M Ostrea; D K Knapp; A Romero; M Montes; A R Ostrea
Journal:  J Pediatr       Date:  1994-03       Impact factor: 4.406

5.  Maternal smoking and fetal growth characteristics in different periods of pregnancy: the generation R study.

Authors:  Vincent W V Jaddoe; Bero O Verburg; M A J de Ridder; Albert Hofman; Johan P Mackenbach; Henriëtte A Moll; Eric A P Steegers; Jacqueline C M Witteman
Journal:  Am J Epidemiol       Date:  2007-02-28       Impact factor: 4.897

6.  Elevated risk of tobacco dependence among offspring of mothers who smoked during pregnancy: a 30-year prospective study.

Authors:  Stephen L Buka; Edmond D Shenassa; Raymond Niaura
Journal:  Am J Psychiatry       Date:  2003-11       Impact factor: 18.112

7.  Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine.

Authors:  N L Benowitz; P Jacob; I Fong; S Gupta
Journal:  J Pharmacol Exp Ther       Date:  1994-01       Impact factor: 4.030

8.  Hair concentrations of nicotine and cotinine in women and their newborn infants.

Authors:  C Eliopoulos; J Klein; M K Phan; B Knie; M Greenwald; D Chitayat; G Koren
Journal:  JAMA       Date:  1994-02-23       Impact factor: 56.272

9.  Cotinine determination by immunoassays may be influenced by other nicotine metabolites.

Authors:  G Schepers; R A Walk
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

10.  Extent of nicotine and cotinine transfer to the human fetus, placenta and amniotic fluid of smoking mothers.

Authors:  W Luck; H Nau; R Hansen; R Steldinger
Journal:  Dev Pharmacol Ther       Date:  1985
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  14 in total

1.  Nicotine and metabolites in meconium as evidence of maternal cigarette smoking during pregnancy and predictors of neonatal growth deficits.

Authors:  Teresa R Gray; Rina D Eiden; Kenneth E Leonard; Gerard Connors; Shannon Shisler; Marilyn A Huestis
Journal:  Nicotine Tob Res       Date:  2010-04-28       Impact factor: 4.244

2.  An epidemiologic study comparing fetal exposure to tobacco smoke in three Southeast Asian countries.

Authors:  Enrique M Ostrea; Esterlita Villanueva-Uy; Sopapan Ngerncham; Luephorn Punnakanta; Melissa J P Batilando; Pratibha Agarwal; Elizabeth Pensler; Melissa Corrion; Erwin F Ramos; Joshua Romero; Ronald L Thomas
Journal:  Int J Occup Environ Health       Date:  2008 Oct-Dec

3.  Optimization and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human oral fluid.

Authors:  Diaa M Shakleya; Marilyn A Huestis
Journal:  Anal Bioanal Chem       Date:  2009-10-18       Impact factor: 4.142

4.  Correlations of maternal buprenorphine dose, buprenorphine, and metabolite concentrations in meconium with neonatal outcomes.

Authors:  S L Kacinko; H E Jones; R E Johnson; R E Choo; M A Huestis
Journal:  Clin Pharmacol Ther       Date:  2008-08-13       Impact factor: 6.875

5.  Simultaneous quantification of buprenorphine, norbuprenorphine, buprenorphine-glucuronide and norbuprenorphine-glucuronide in human umbilical cord by liquid chromatography tandem mass spectrometry.

Authors:  Marta Concheiro; Diaa M Shakleya; Marilyn A Huestis
Journal:  Forensic Sci Int       Date:  2009-04-29       Impact factor: 2.395

6.  Simultaneous quantification of nicotine, opioids, cocaine, and metabolites in human fetal postmortem brain by liquid chromatography tandem mass spectrometry.

Authors:  Diaa M Shakleya; Marilyn A Huestis
Journal:  Anal Bioanal Chem       Date:  2009-02-21       Impact factor: 4.142

7.  Meconium nicotine and metabolites by liquid chromatography-tandem mass spectrometry: differentiation of passive and nonexposure and correlation with neonatal outcome measures.

Authors:  Teresa R Gray; Raquel Magri; Diaa M Shakleya; Marilyn A Huestis
Journal:  Clin Chem       Date:  2008-10-09       Impact factor: 8.327

8.  Simultaneous quantification of methadone, cocaine, opiates, and metabolites in human placenta by liquid chromatography-mass spectrometry.

Authors:  Ana de Castro; Marta Concheiro; Diaa M Shakleya; Marilyn A Huestis
Journal:  J Anal Toxicol       Date:  2009-06       Impact factor: 3.367

9.  Simultaneous and sensitive measurement of nicotine, cotinine, trans-3'-hydroxycotinine and norcotinine in human plasma by liquid chromatography-tandem mass spectrometry.

Authors:  Diaa M Shakleya; Marilyn A Huestis
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2009-08-28       Impact factor: 3.205

10.  A liquid chromatography tandem mass spectrometry method for the simultaneous quantification of 20 drugs of abuse and metabolites in human meconium.

Authors:  Teresa R Gray; Diaa M Shakleya; Marilyn A Huestis
Journal:  Anal Bioanal Chem       Date:  2009-02-26       Impact factor: 4.142
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