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Literature DB >> 18243696

A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy.

Yoshiyuki Yoneda¹, Sebastian C J Steiniger, Katerina Capková, Jenny M Mee, Ying Liu, Gunnar F Kaufmann, Kim D Janda.

Abstract

Tumor targeting peptides are promising vehicles for site-directed cancer therapy. Pep42, a cyclic 13-mer oligopeptide that specifically binds to glucose-regulated protein 78 (GRP78) and internalized into cancer cells, represents an excellent vehicle for tumor cell-specific chemotherapy. Here, we report the synthesis and evaluation of Pep42-prodrug conjugates that contain a cathepsin B-cleavable linker, resulting in the traceless release of drug inside the cancer cells.

Entities: Disease Gene

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Year: 2008 PMID： 18243696 PMCID： PMC2288489 DOI： 10.1016/j.bmcl.2008.01.060

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

17 in total

1. Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery.

Authors: Xiaoyuan Chen; Carmen Plasencia; Yingping Hou; Nouri Neamati
Journal: J Med Chem Date: 2005-02-24 Impact factor: 7.446

2. Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand.

Authors: Youngsoo Kim; Antonietta M Lillo; Sebastian C J Steiniger; Ying Liu; Carlo Ballatore; Andrea Anichini; Roberta Mortarini; Gunnar F Kaufmann; Bin Zhou; Brunhilde Felding-Habermann; Kim D Janda
Journal: Biochemistry Date: 2006-08-08 Impact factor: 3.162

3. Self-immolative anthracycline prodrugs for suicide gene therapy.

Authors: I Niculescu-Duvaz; D Niculescu-Duvaz; F Friedlos; R Spooner; J Martin; R Marais; C J Springer
Journal: J Med Chem Date: 1999-07-01 Impact factor: 7.446

4. Paclitaxel derivatives for targeted therapy of cancer: toward the development of smart taxanes.

Authors: A Safavy; K P Raisch; M B Khazaeli; D J Buchsbaum; J A Bonner
Journal: J Med Chem Date: 1999-11-18 Impact factor: 7.446

5. Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy.

Authors: Björn Schmid; Da-Eun Chung; André Warnecke; Iduna Fichtner; Felix Kratz
Journal: Bioconjug Chem Date: 2007-03-23 Impact factor: 4.774

6. Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery.

Authors: Ying Liu; Sebastian C J Steiniger; YoungSoo Kim; Gunnar F Kaufmann; Brunhilde Felding-Habermann; Kim D Janda
Journal: Mol Pharm Date: 2007-03-21 Impact factor: 4.939

7. Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer.

Authors: Jun Zhang; Yixing Jiang; Zhiliang Jia; Qiang Li; Weida Gong; Liwei Wang; Daoyan Wei; James Yao; Shengyun Fang; Keping Xie
Journal: Clin Exp Metastasis Date: 2006-12-23 Impact factor: 5.150

8. Synthesis and biological in vitro evaluation of novel PEG-psoralen conjugates.

Authors: F Bettio; M Canevari; C Marzano; F Bordin; A Guiotto; F Greco; R Duncan; F M Veronese
Journal: Biomacromolecules Date: 2006-12 Impact factor: 6.988

Review 9. Glucose regulated proteins in cancer progression, drug resistance and immunotherapy.

Authors: Yong Fu; Amy S Lee
Journal: Cancer Biol Ther Date: 2006-07-01 Impact factor: 4.742

10. Protease-mediated fragmentation of p-amidobenzyl ethers: a new strategy for the activation of anticancer prodrugs.

Authors: Brian E Toki; Charles G Cerveny; Alan F Wahl; Peter D Senter
Journal: J Org Chem Date: 2002-03-22 Impact factor: 4.354

26 in total

1. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.

Authors: Shiuan Wey; Biquan Luo; Chun-Chih Tseng; Min Ni; Hui Zhou; Yong Fu; Deepa Bhojwani; William L Carroll; Amy S Lee
Journal: Blood Date: 2011-09-21 Impact factor: 22.113

A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy.

1. Synthesis and biological evaluation of dimeric RGD peptide-paclitaxel conjugate as a model for integrin-targeted drug delivery.

2. Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand.

3. Self-immolative anthracycline prodrugs for suicide gene therapy.

4. Paclitaxel derivatives for targeted therapy of cancer: toward the development of smart taxanes.

5. Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy.

6. Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery.

7. Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer.

8. Synthesis and biological in vitro evaluation of novel PEG-psoralen conjugates.

Review 9. Glucose regulated proteins in cancer progression, drug resistance and immunotherapy.

10. Protease-mediated fragmentation of p-amidobenzyl ethers: a new strategy for the activation of anticancer prodrugs.

1. Inducible knockout of GRP78/BiP in the hematopoietic system suppresses Pten-null leukemogenesis and AKT oncogenic signaling.

Review 2. Targeted delivery with peptidomimetic conjugated self-assembled nanoparticles.

Review 3. Combinatorial peptide libraries: mining for cell-binding peptides.

4. Artificial neural network study on organ-targeting peptides.

5. Identification of tissue-specific targeting peptide.

6. Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors.

7. Identification of a LNCaP-specific binding peptide using phage display.

Review 8. Unfolded Protein Response as a Therapeutic Target in Cardiovascular Disease.

9. Synthesis and biological evaluation of a peptide-paclitaxel conjugate which targets the integrin αvβ₆.

Review 10. The biological and therapeutic relevance of mRNA translation in cancer.