| Literature DB >> 18243529 |
Kosuke Yanai1, Masafumi Nakamura, Takashi Akiyoshi, Shuntaro Nagai, Junji Wada, Kenichiro Koga, Hirokazu Noshiro, Eishi Nagai, Masazumi Tsuneyoshi, Masao Tanaka, Mitsuo Katano.
Abstract
Morphogenic signals like Hedgehog (Hh) and Wnt are reported to play critical roles in the progression of gastric cancer. We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway activation. When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear beta-catenin accumulation and proliferation of AGS cells. Knock-down of beta-catenin by siRNA suppressed Wnt pathway activity and proliferation of AGS cells. Our data may provide some clues for the treatment of gastric cancer associated with Wnt signaling activation.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18243529 DOI： 10.1016/j.canlet.2007.12.030
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679