| Literature DB >> 18243266 |
Yliana López1, Izabella Jastrzebska, Rosa Santillan, Jacek W Morzycki.
Abstract
The synthesis of two "glycospirostanes" from 23-oxotigogenin acetate is described. (23S,24S,25R)-5alpha-Spirostane-3beta,23,24,25-tetraol was obtained by dehydrogenation followed by stereoselective reduction of the 23-oxo group and OsO(4) dihydroxylation of the C24-C25 double bond. Allylic hydroxylation with SeO(2) of 3beta-acetoxy-5alpha-spirost-23-ene obtained from 23-oxotigogenin acetate followed by OsO(4) dihydroxylation of the C23-C24 double bond afforded (23R,24S,25R)-5alpha-spirostane-3beta,23,24,25-tetraol.Entities:
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Year: 2008 PMID： 18243266 DOI： 10.1016/j.steroids.2007.12.015
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668