BACKGROUND: Cognitive impairment that does not meet the criteria for dementia ("Cognitive Impairment, No Dementia" -- CIND) is a heterogeneous category with an increased risk of dementia. While greater physical activity is generally associated with a lower odds of both dementia and CIND, whether this effect applies across subgroups is not known. OBJECTIVES: To investigate the association between physical activity and the risk of vascular CIND (VCI-ND) or mild cognitive impairment (MCI). METHODS: In the Canadian Study of Health and Aging community-dwelling cohort, of 4683 people who were not impaired at baseline, 3945 remained without cognitive impairment at 5 years, 454 were diagnosed with CIND, and 284 with dementia. Incident CIND and VCI-ND (n=163) and MCI (n=100) subtypes were investigated in relation to baseline physical activity, stratified by sex. RESULTS: In women, moderate-high exercise was associated with a lower odds of CIND (OR=0.62, 95% CI=0.46-0.84) and VCI-ND (0.34, 0.18-0.63) relative to low exercise. There was no association for men or for MCI. CONCLUSION: Exercise appears to reduce the risk of VCI-ND in women. Whether the lack of an effect of exercise on the odds of MCI reflects that 'prevented AD' is indistinguishable from MCI is an intriguing possibility that merits further study.
BACKGROUND:Cognitive impairment that does not meet the criteria for dementia ("Cognitive Impairment, No Dementia" -- CIND) is a heterogeneous category with an increased risk of dementia. While greater physical activity is generally associated with a lower odds of both dementia and CIND, whether this effect applies across subgroups is not known. OBJECTIVES: To investigate the association between physical activity and the risk of vascular CIND (VCI-ND) or mild cognitive impairment (MCI). METHODS: In the Canadian Study of Health and Aging community-dwelling cohort, of 4683 people who were not impaired at baseline, 3945 remained without cognitive impairment at 5 years, 454 were diagnosed with CIND, and 284 with dementia. Incident CIND and VCI-ND (n=163) and MCI (n=100) subtypes were investigated in relation to baseline physical activity, stratified by sex. RESULTS: In women, moderate-high exercise was associated with a lower odds of CIND (OR=0.62, 95% CI=0.46-0.84) and VCI-ND (0.34, 0.18-0.63) relative to low exercise. There was no association for men or for MCI. CONCLUSION: Exercise appears to reduce the risk of VCI-ND in women. Whether the lack of an effect of exercise on the odds of MCI reflects that 'prevented AD' is indistinguishable from MCI is an intriguing possibility that merits further study.
Authors: Ryan J Dougherty; Elizabeth A Boots; Jacob B Lindheimer; Aaron J Stegner; Stephanie Van Riper; Dorothy F Edwards; Catherine L Gallagher; Cynthia M Carlsson; Howard A Rowley; Barbara B Bendlin; Sanjay Asthana; Bruce P Hermann; Mark A Sager; Sterling C Johnson; Ozioma C Okonkwo; Dane B Cook Journal: Brain Imaging Behav Date: 2020-08 Impact factor: 3.978
Authors: Lindsay S Nagamatsu; Leon Flicker; Arthur F Kramer; Michelle W Voss; Kirk I Erickson; Chun Liang Hsu; Teresa Liu-Ambrose Journal: Br J Sports Med Date: 2014-03-21 Impact factor: 13.800
Authors: James A Blumenthal; Patrick J Smith; Kathleen Welsh-Bohmer; Michael A Babyak; Jeffrey Browndyke; Pao-Hwa Lin; P Murali Doraiswamy; James Burke; William Kraus; Alan Hinderliter; Andrew Sherwood Journal: Contemp Clin Trials Date: 2012-09-19 Impact factor: 2.226