| Literature DB >> 18242988 |
Martin E Hayes1, Grier A Wallace, Pintipa Grongsaard, Agnieszka Bischoff, Dawn M George, Wenyan Miao, Michael J McPherson, Robert H Stoffel, David W Green, Gregory P Roth.
Abstract
High-throughput screening identified a low molecular weight antagonist of CXCR3 displaying micromolar activity in a membrane filtration-binding assay. Systematic modification of the benzimidazole core and tethered acetophenone moiety established tractable SAR of analogs with improved physicochemical properties and sub-micromolar activity across both human and murine receptors.Entities:
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Year: 2008 PMID： 18242988 DOI： 10.1016/j.bmcl.2008.01.074
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823