Literature DB >> 18242665

What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: Findings from the NLTCS-Medicare data.

Anatoli I Yashin1, Konstantin G Arbeev, Alexander Kulminski, Igor Akushevich, Lucy Akushevich, Svetlana V Ukraintseva.   

Abstract

An important feature of aging-related deterioration in human health is the decline in organisms' resistance to stresses, which contributes to an increase in morbidity and mortality risks. In human longitudinal studies of aging, such a decline is not measured directly, so indirect methods of statistical modeling have to be used for evaluating this characteristic. Since medical interventions reflect severity of occurring health disorders, data from Medicare service use files can be used for such modeling. In this paper, we use the National Long Term Care Survey (NLTCS) data merged with the Medicare service use files to investigate dynamics of stress resistance in the U.S. elderly. We constructed individual indices of cumulative deficits and medical costs and investigated their separate and joint effects on dynamics of mortality risks using the quadratic hazard model (QHM). We found that males show a faster decline in stress resistance with age than females.

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Year:  2008        PMID: 18242665      PMCID: PMC2289773          DOI: 10.1016/j.mad.2007.12.005

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN: 0047-6374            Impact factor:   5.432


  27 in total

1.  Accumulation of health disorders as a systemic measure of aging: Findings from the NLTCS data.

Authors:  Alexander Kulminski; Anatoli Yashin; Svetlana Ukraintseva; Igor Akushevich; Konstantin Arbeev; Kenneth Land; Kenneth Manton
Journal:  Mech Ageing Dev       Date:  2006-09-14       Impact factor: 5.432

2.  Decrease in the relative heterogeneity of health with age: a cross-national comparison.

Authors:  Arnold Mitnitski; Kenneth Rockwood
Journal:  Mech Ageing Dev       Date:  2005-10-27       Impact factor: 5.432

3.  Consequences of health trends and medical innovation for the future elderly.

Authors:  Dana P Goldman; Baoping Shang; Jayanta Bhattacharya; Alan M Garber; Michael Hurd; Geoffrey F Joyce; Darius N Lakdawalla; Constantijn Panis; Paul G Shekelle
Journal:  Health Aff (Millwood)       Date:  2005       Impact factor: 6.301

4.  The relationship between ex ante mortality risk and end-of-life medical costs.

Authors:  David H Howard; Steven D Culler; Benjamin G Druss; Kenneth E Thorpe
Journal:  Appl Health Econ Health Policy       Date:  2006       Impact factor: 2.561

5.  Just what defines frailty?

Authors:  Alfred L Fisher
Journal:  J Am Geriatr Soc       Date:  2005-12       Impact factor: 5.562

6.  Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey.

Authors:  A Kulminski; A Yashin; K Arbeev; I Akushevich; S Ukraintseva; K Land; K Manton
Journal:  Mech Ageing Dev       Date:  2006-12-20       Impact factor: 5.432

7.  Health decline, aging and mortality: how are they related?

Authors:  Anatoli I Yashin; Konstantin G Arbeev; Aliaksandr Kulminski; Igor Akushevich; Lucy Akushevich; Svetlana V Ukraintseva
Journal:  Biogerontology       Date:  2007-01-23       Impact factor: 4.277

8.  Cumulative index of elderly disorders and its dynamic contribution to mortality and longevity.

Authors:  Anatoli I Yashin; Konstantin G Arbeev; Alexander Kulminski; Igor Akushevich; Lucy Akushevich; Svetlana V Ukraintseva
Journal:  Rejuvenation Res       Date:  2007-03       Impact factor: 4.663

9.  Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70.

Authors:  Kenneth Rockwood; Arnold Mitnitski; Xiaowei Song; Bertil Steen; Ingmar Skoog
Journal:  J Am Geriatr Soc       Date:  2006-06       Impact factor: 5.562

10.  Cumulative index of health deficiencies as a characteristic of long life.

Authors:  Alexander M Kulminski; Svetlana V Ukraintseva; Igor V Akushevich; Konstantin G Arbeev; Anatoli I Yashin
Journal:  J Am Geriatr Soc       Date:  2007-06       Impact factor: 5.562

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  13 in total

1.  New stochastic carcinogenesis model with covariates: an approach involving intracellular barrier mechanisms.

Authors:  Igor Akushevich; Galina Veremeyeva; Julia Kravchenko; Svetlana Ukraintseva; Konstantin Arbeev; Alexander V Akleyev; Anatoly I Yashin
Journal:  Math Biosci       Date:  2011-12-17       Impact factor: 2.144

2.  Age trajectories of physiological indices in relation to healthy life course.

Authors:  Konstantin G Arbeev; Svetlana V Ukraintseva; Igor Akushevich; Alexander M Kulminski; Liubov S Arbeeva; Lucy Akushevich; Irina V Culminskaya; Anatoliy I Yashin
Journal:  Mech Ageing Dev       Date:  2011-01-22       Impact factor: 5.432

3.  How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.

Authors:  Anatoliy I Yashin; Konstantin G Arbeev; Deqing Wu; Liubov Arbeeva; Alexander Kulminski; Irina Kulminskaya; Igor Akushevich; Svetlana V Ukraintseva
Journal:  N Am Actuar J       Date:  2016-06-22

4.  The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span.

Authors:  A I Yashin; K G Arbeev; I Akushevich; A Kulminski; S V Ukraintseva; E Stallard; K C Land
Journal:  Phys Life Rev       Date:  2012-05-17       Impact factor: 11.025

5.  Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data.

Authors:  Konstantin G Arbeev; Igor Akushevich; Alexander M Kulminski; Liubov S Arbeeva; Lucy Akushevich; Svetlana V Ukraintseva; Irina V Culminskaya; Anatoli I Yashin
Journal:  J Theor Biol       Date:  2009-02-04       Impact factor: 2.691

Review 6.  Dynamics of biomarkers in relation to aging and mortality.

Authors:  Konstantin G Arbeev; Svetlana V Ukraintseva; Anatoliy I Yashin
Journal:  Mech Ageing Dev       Date:  2016-04-29       Impact factor: 5.432

7.  The impact of adverse events on health care costs for older adults undergoing nonelective abdominal surgery.

Authors:  Jonathan G Bailey; Philip J B Davis; Adrian R Levy; Michele Molinari; Paul M Johnson
Journal:  Can J Surg       Date:  2016-06       Impact factor: 2.089

Review 8.  A review of selected longitudinal studies on aging: past findings and future directions.

Authors:  Damian C Stanziano; Michael Whitehurst; Patricia Graham; Bernard A Roos
Journal:  J Am Geriatr Soc       Date:  2010-10       Impact factor: 5.562

9.  Studying health histories of cancer: a new model connecting cancer incidence and survival.

Authors:  Anatoli I Yashin; Igor Akushevich; Konstantin Arbeev; Lucy Akushevich; Alexander Kulminski; Svetlana Ukraintseva
Journal:  Math Biosci       Date:  2009-01-04       Impact factor: 2.144

10.  Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging.

Authors:  Konstantin G Arbeev; Svetlana V Ukraintseva; Alexander M Kulminski; Igor Akushevich; Liubov S Arbeeva; Irina V Culminskaya; Deqing Wu; Anatoliy I Yashin
Journal:  Scientifica (Cairo)       Date:  2012
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