| Literature DB >> 18242515 |
Zhen Fan Yang1, David W Ho, Michael N Ng, Chi Keung Lau, Wan Ching Yu, Patricia Ngai, Patrick W K Chu, Chi Tat Lam, Ronnie T P Poon, Sheung Tat Fan.
Abstract
This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples. The CD90+ cells, but not the CD90(-) cells, from HCC cell lines displayed tumorigenic capacity. All the tumor specimens and 91.6% of blood samples from liver cancer patients bore the CD45(-)CD90+ population, which could generate tumor nodules in immunodeficient mice. The CD90+CD44+ cells demonstrated a more aggressive phenotype than the CD90+CD44(-) counterpart and formed metastatic lesions in the lung of immunodeficient mice. CD44 blockade prevented the formation of local and metastatic tumor nodules by the CD90+ cells. Differential gene expression profiles were identified in the CD45(-)CD90+ and CD45(-)CD90(-) cells isolated from tissue and blood samples from liver cancer patients and controls.Entities:
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Year: 2008 PMID： 18242515 DOI： 10.1016/j.ccr.2008.01.013
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743