| Literature DB >> 18242191 |
Fumiko Suenaga1, Kyosuke Hatsushika, Shinichi Takano, Takashi Ando, Yuko Ohnuma, Hideoki Ogawa, Atsuhito Nakao.
Abstract
Resveratrol, a polyphenolic compound found in the skin of red fruits, exhibits anti-inflammatory, anti-oxidative, and anti-proliferative characteristics. Transforming growth factor-beta (TGF-beta) is a pleiotropic cytokine that also displays such properties. We therefore hypothesized that there might be a functional link between resveratrol and TGF-beta. This study reports that resveratrol increased transcription of the TGF-beta2 gene, enhanced the production of TGF-beta2 protein, and activated Smad signaling in an autocrine manner in A549 human lung epithelial cell line. Thus, some of the beneficial effects of resveratrol on human health might be mediated, in part, through its effects on TGF-beta expression and signaling.Entities:
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Year: 2008 PMID： 18242191 DOI： 10.1016/j.febslet.2008.01.024
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124