Literature DB >> 18242088

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.

Yuefen Zhou1, Stephen E Webber, Douglas E Murphy, Lian-Sheng Li, Peter S Dragovich, Chinh V Tran, Zhongxiang Sun, Frank Ruebsam, Amit M Shah, Mei Tsan, Richard E Showalter, Rupal Patel, Bin Li, Qiang Zhao, Qing Han, Thomas Hermann, Charles R Kissinger, Laurie Lebrun, Maria V Sergeeva, Leo Kirkovsky.   

Abstract

5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The synthesis, structure-activity relationships (SAR), metabolic stability, and structure-based design approach for this new class of compounds are discussed.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18242088     DOI： 10.1016/j.bmcl.2008.01.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Discovering protein-ligand chalcogen bonding in the protein data bank using endocyclic sulfur-containing heterocycles as ligand search subsets.

Authors:  Miguel O Mitchell
Journal:  J Mol Model       Date:  2017-09-24       Impact factor: 1.810

2.  QSAR study of C allosteric binding site of HCV NS5B polymerase inhibitors by support vector machine.

Authors:  Eslam Pourbasheer; Siavash Riahi; Mohammad Reza Ganjali; Parviz Norouzi
Journal:  Mol Divers       Date:  2010-10-08       Impact factor: 2.943

3.  In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor.

Authors:  Warren Kati; Gennadiy Koev; Michelle Irvin; Jill Beyer; Yaya Liu; Preethi Krishnan; Thomas Reisch; Rubina Mondal; Rolf Wagner; Akhteruzzaman Molla; Clarence Maring; Christine Collins
Journal:  Antimicrob Agents Chemother       Date:  2014-12-22       Impact factor: 5.191

4.  An Efficient Modern Strategy to Screen Drug Candidates Targeting RdRp of SARS-CoV-2 With Potentially High Selectivity and Specificity.

Authors:  Haiping Zhang; Xiaohua Gong; Yun Peng; Konda Mani Saravanan; Hengwei Bian; John Z H Zhang; Yanjie Wei; Yi Pan; Yang Yang
Journal:  Front Chem       Date:  2022-07-12       Impact factor: 5.545

5.  Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.

Authors:  Iwona E Weidlich; Igor V Filippov; Jodian Brown; Neerja Kaushik-Basu; Ramalingam Krishnan; Marc C Nicklaus; Ian F Thorpe
Journal:  Bioorg Med Chem       Date:  2013-03-29       Impact factor: 3.641

6.  Classification of HCV NS5B polymerase inhibitors using support vector machine.

Authors:  Maolin Wang; Kai Wang; Aixia Yan; Changyuan Yu
Journal:  Int J Mol Sci       Date:  2012-03-27       Impact factor: 6.208
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.