Literature DB >> 18242087

Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.

Huaiyu Yang1, Wei Dou, Jing Lou, Ying Leng, Jianhua Shen.   

Abstract

11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is a potential target for treatment of diabetes and metabolic syndrome. Docking and pharmacophore modeling have been used to discover novel inhibitors of 11beta-HSD1. Several compounds, with large structural diversity and good potency against 11beta-HSD1, have been found and their potency was determined by the enzyme assay. New scaffolds of 11beta-HSD1 inhibitors are also reported.

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Year:  2008        PMID： 18242087     DOI： 10.1016/j.bmcl.2008.01.020

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

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Review 3.  The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease.

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4.  Identification of important chemical features of 11β-hydroxysteroid dehydrogenase type1 inhibitors: application of ligand based virtual screening and density functional theory.

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6.  16-nor Limonoids from Harrisonia perforata as promising selective 11β-HSD1 inhibitors.

Authors:  Xiao-Hui Yan; Ping Yi; Pei Cao; Shi-Ying Yang; Xin Fang; Yu Zhang; Ying Leng; Ying-Tong Di; Yang Lv; Xiao-Jiang Hao
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Review 7.  Enteric Microbiota⁻Gut⁻Brain Axis from the Perspective of Nuclear Receptors.

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8.  A new triterpenoid from Teucrium viscidum.

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Journal:  Molecules       Date:  2013-01-21       Impact factor: 4.411

9.  Inhibition of 11b-HSD1 by tetracyclic triterpenoids from Euphorbia kansui.

Authors:  Jie Guo; Li-Yan Zhou; Hong-Ping He; Ying Leng; Zhen Yang; Xiao-Jiang Hao
Journal:  Molecules       Date:  2012-10-09       Impact factor: 4.411

Review 10.  Pharmacophore Models and Pharmacophore-Based Virtual Screening: Concepts and Applications Exemplified on Hydroxysteroid Dehydrogenases.

Authors:  Teresa Kaserer; Katharina R Beck; Muhammad Akram; Alex Odermatt; Daniela Schuster
Journal:  Molecules       Date:  2015-12-19       Impact factor: 4.411
  10 in total

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