OBJECTIVE: Recent studies indicate that circulating calprotectin may serve as a biomarker in some cancers. We investigated whether this is the case for ovarian neoplasms. STUDY DESIGN: Calprotectin was analyzed with an enzyme-linked immunosorbent assay in EDTA-plasma collected prior to surgery from women with ovarian carcinomas (n = 89), borderline ovarian tumors (BOT, n = 39), and benign ovarian tumors (n = 71). Serum CA 125 was analyzed in the same study population. RESULTS: Median plasma calprotectin concentration was elevated in ovarian carcinoma, compared with controls, as well as compared with BOT (both P < .001). A positive correlation was found between CA 125 and calprotectin concentrations in ovarian carcinoma. Receiver operating characteristic curves demonstrated a larger area under the curve for CA 125 (0.85) as compared with calprotectin (0.70). CONCLUSION: Plasma calprotectin is elevated in invasive ovarian cancer, but when used as a tumor marker, it is inferior to CA 125.
OBJECTIVE: Recent studies indicate that circulating calprotectin may serve as a biomarker in some cancers. We investigated whether this is the case for ovarian neoplasms. STUDY DESIGN: Calprotectin was analyzed with an enzyme-linked immunosorbent assay in EDTA-plasma collected prior to surgery from women with ovarian carcinomas (n = 89), borderline ovarian tumors (BOT, n = 39), and benign ovarian tumors (n = 71). Serum CA 125 was analyzed in the same study population. RESULTS: Median plasma calprotectin concentration was elevated in ovarian carcinoma, compared with controls, as well as compared with BOT (both P < .001). A positive correlation was found between CA 125 and calprotectin concentrations in ovarian carcinoma. Receiver operating characteristic curves demonstrated a larger area under the curve for CA 125 (0.85) as compared with calprotectin (0.70). CONCLUSION: Plasma calprotectin is elevated in invasive ovarian cancer, but when used as a tumor marker, it is inferior to CA 125.
Authors: Prokopios P Argyris; Zachary Slama; Chris Malz; Ioannis G Koutlas; Betty Pakzad; Ketan Patel; Deepak Kademani; Ali Khammanivong; Mark C Herzberg Journal: Oral Oncol Date: 2019-06-04 Impact factor: 5.337
Authors: Muhammet Fatih Topuz; Adem Binnetoglu; Ali Cemal Yumusakhuylu; Murat Sarı; Tekin Baglam; Fetullah Gerin Journal: Eur Arch Otorhinolaryngol Date: 2017-03-01 Impact factor: 2.503
Authors: Matthew R Russell; Ciaren Graham; Alfonsina D'Amato; Aleksandra Gentry-Maharaj; Andy Ryan; Jatinderpal K Kalsi; Carol Ainley; Anthony D Whetton; Usha Menon; Ian Jacobs; Robert L J Graham Journal: Br J Cancer Date: 2017-06-29 Impact factor: 7.640