BACKGROUND: Several lines of evidence from animal and electrophysiological studies indicate that the neuropeptide Y (NPY) gene is involved in the pathophysiology of alcohol dependence. Recent studies have provided evidence for an association between a Leu7Pro polymorphism, as well as 2 promoter single nucleotide polymorphisms (SNPs) in the NPY gene (G-602T, T-399C) and alcohol dependence. The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism. METHODS: We performed single SNP and haplotype studies in 465 alcohol dependent patients and 448 healthy controls with 3 SNPs in the promoter region (-883ins/del, G-602T, T-399C) and the Leu7Pro polymorphism in exon 2 of the NPY gene. RESULTS: Neither single SNP-, nor haplotype analysis could detect significant associations with alcohol dependence. Additionally we could not detect any relation to Cloninger's Type 1/2 or Babor's Type A/B classification, to withdrawal symptoms, to the age of onset or to the amount of alcohol intake. CONCLUSIONS: In conclusion, our results suggest that the analyzed SNPs, as well as the corresponding haplotypes of the NPY gene are unlikely to play a major role in the pathophysiology of alcohol dependence in the investigated sample from the German population. Further analyses are needed to confirm the present results.
BACKGROUND: Several lines of evidence from animal and electrophysiological studies indicate that the neuropeptide Y (NPY) gene is involved in the pathophysiology of alcohol dependence. Recent studies have provided evidence for an association between a Leu7Pro polymorphism, as well as 2 promoter single nucleotide polymorphisms (SNPs) in the NPY gene (G-602T, T-399C) and alcohol dependence. The aim of the present study was to analyze these variants in a large sample of the Munich Gene Bank of Alcoholism. METHODS: We performed single SNP and haplotype studies in 465 alcohol dependent patients and 448 healthy controls with 3 SNPs in the promoter region (-883ins/del, G-602T, T-399C) and the Leu7Pro polymorphism in exon 2 of the NPY gene. RESULTS: Neither single SNP-, nor haplotype analysis could detect significant associations with alcohol dependence. Additionally we could not detect any relation to Cloninger's Type 1/2 or Babor's Type A/B classification, to withdrawal symptoms, to the age of onset or to the amount of alcohol intake. CONCLUSIONS: In conclusion, our results suggest that the analyzed SNPs, as well as the corresponding haplotypes of the NPY gene are unlikely to play a major role in the pathophysiology of alcohol dependence in the investigated sample from the German population. Further analyses are needed to confirm the present results.
Authors: Wolfgang H Sommer; Jessica Lidström; Hui Sun; Derek Passer; Robert Eskay; Stephen C J Parker; Stephanie H Witt; Ulrich S Zimmermann; Vanessa Nieratschker; Marcella Rietschel; Elliott H Margulies; Miklós Palkovits; Manfred Laucht; Markus Heilig Journal: Hum Mutat Date: 2010-08 Impact factor: 4.878
Authors: Stephen G Lindell; Melanie L Schwandt; Hui Sun; Jeffrey D Sparenborg; Karl Björk; John W Kasckow; Wolfgang H Sommer; David Goldman; J Dee Higley; Stephen J Suomi; Markus Heilig; Christina S Barr Journal: Arch Gen Psychiatry Date: 2010-04
Authors: Ke Xu; Kwangik Adam Hong; Zhifeng Zhou; Richard L Hauger; David Goldman; Rajita Sinha Journal: Psychoneuroendocrinology Date: 2011-09-13 Impact factor: 4.905
Authors: Leah Wetherill; Marc A Schuckit; Victor Hesselbrock; Xiaoling Xuei; Tiebing Liang; Danielle M Dick; John Kramer; John I Nurnberger; Jay A Tischfield; Bernice Porjesz; Howard J Edenberg; Tatiana Foroud Journal: Alcohol Clin Exp Res Date: 2008-09-25 Impact factor: 3.455