| Literature DB >> 18240388 |
Dong-Mei Feng1, Robert M DiPardo, Jenny M Wai, Ronald K Chang, Christina N Di Marco, Kathy L Murphy, Richard W Ransom, Duane R Reiss, Cuyue Tang, Thomayant Prueksaritanont, Douglas J Pettibone, Mark G Bock, Scott D Kuduk.
Abstract
The design and synthesis of a novel class of human bradykinin B1 antagonists featuring difluoroethyl ether and isoxazole carboxamide moieties are disclosed. Compound 7g displayed excellent pharmacokinetic properties, efficient ex vivo receptor occupancy, and low potential for P450 induction via PXR activation.Entities:
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Year: 2008 PMID： 18240388 DOI： 10.1016/j.bmcl.2007.11.057
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823