OBJECTIVE: A subset of fibromyalgia (FM) patients have a dysfunctional hypothalamic-pituitary-insulin-like growth factor 1 (IGF-1) axis, as evidenced by low serum levels of IGF-1 and a reduced growth hormone (GH) response to physiologic stimuli. There is evidence that pyridostigmine (PYD) improves the acute response of GH to exercise in FM patients. The purpose of this study was to evaluate the clinical effectiveness of 6 months of PYD and group exercise on FM symptoms. METHODS:FM patients were randomized to 1 of the following 4 groups: PYD plus exercise, PYD plus diet recall but no exercise, placebo plus exercise, and placebo plus diet recall but no exercise. The primary outcome measures were the visual analog scale (VAS) score for pain, tender point count, and total myalgic score. Secondary outcome measures were the total score on the Fibromyalgia Impact Questionnaire (FIQ) and FIQ VAS scores for individual symptoms (fatigue, poor sleep, stiffness, and anxiety), as well as quality of life (QOL) and physical fitness (lower body strength/endurance, upper and lower body flexibility, balance, and time on the treadmill). RESULTS: A total of 165 FM patients completed baseline measurements; 154 (93.3%) completed the study. The combination of PYD and exercise did not improve pain scores. PYD groups showed a significant improvement in sleep and anxiety in those who completed the study and in QOL in those who complied with the therapeutic regimen as compared with the placebo groups. Compared with the nonexercise groups, the 2 exercise groups demonstrated improvement in fatigue and fitness. PYD was generally well tolerated. CONCLUSION: Neither the combination of PYD plus supervised exercise nor either treatment alone yielded improvement in most FM symptoms. However, PYD did improve anxiety and sleep, and exercise improved fatigue and fitness. We speculate that PYD may have improved vagal tone, thus benefiting sleep and anxiety; this notion warrants further study.
RCT Entities:
OBJECTIVE: A subset of fibromyalgia (FM) patients have a dysfunctional hypothalamic-pituitary-insulin-like growth factor 1 (IGF-1) axis, as evidenced by low serum levels of IGF-1 and a reduced growth hormone (GH) response to physiologic stimuli. There is evidence that pyridostigmine (PYD) improves the acute response of GH to exercise in FM patients. The purpose of this study was to evaluate the clinical effectiveness of 6 months of PYD and group exercise on FM symptoms. METHODS: FM patients were randomized to 1 of the following 4 groups: PYD plus exercise, PYD plus diet recall but no exercise, placebo plus exercise, and placebo plus diet recall but no exercise. The primary outcome measures were the visual analog scale (VAS) score for pain, tender point count, and total myalgic score. Secondary outcome measures were the total score on the Fibromyalgia Impact Questionnaire (FIQ) and FIQ VAS scores for individual symptoms (fatigue, poor sleep, stiffness, and anxiety), as well as quality of life (QOL) and physical fitness (lower body strength/endurance, upper and lower body flexibility, balance, and time on the treadmill). RESULTS: A total of 165 FM patients completed baseline measurements; 154 (93.3%) completed the study. The combination of PYD and exercise did not improve pain scores. PYD groups showed a significant improvement in sleep and anxiety in those who completed the study and in QOL in those who complied with the therapeutic regimen as compared with the placebo groups. Compared with the nonexercise groups, the 2 exercise groups demonstrated improvement in fatigue and fitness. PYD was generally well tolerated. CONCLUSION: Neither the combination of PYD plus supervised exercise nor either treatment alone yielded improvement in most FM symptoms. However, PYD did improve anxiety and sleep, and exercise improved fatigue and fitness. We speculate that PYD may have improved vagal tone, thus benefiting sleep and anxiety; this notion warrants further study.
Authors: Thomas A Dewland; Ana Silvia Androne; Forrester A Lee; Rachel J Lampert; Stuart D Katz Journal: Am J Physiol Heart Circ Physiol Date: 2007-02-23 Impact factor: 4.733
Authors: Afton L Hassett; Diane C Radvanski; Evgeny G Vaschillo; Bronya Vaschillo; Leonard H Sigal; Maria Katsamanis Karavidas; Steven Buyske; Paul M Lehrer Journal: Appl Psychophysiol Biofeedback Date: 2007-01-12
Authors: Samuel A McLean; David A Williams; Phyllis K Stein; Richard E Harris; Angela K Lyden; Gail Whalen; Karen M Park; Israel Liberzon; Ananda Sen; Richard H Gracely; James N Baraniuk; Daniel J Clauw Journal: Neuropsychopharmacology Date: 2006-08-23 Impact factor: 7.853
Authors: Kim Dupree Jones; Atul A Deodhar; Carol S Burckhardt; Nancy A Perrin; Ginger C Hanson; Robert M Bennett Journal: J Rheumatol Date: 2007-04-01 Impact factor: 4.666
Authors: Kim Dupree Jones; Dianne Adams; Kerri Winters-Stone; Carol S Burckhardt Journal: Health Qual Life Outcomes Date: 2006-09-25 Impact factor: 3.186
Authors: A Winkelmann; W Häuser; E Friedel; M Moog-Egan; D Seeger; M Settan; T Weiss; M Schiltenwolf Journal: Schmerz Date: 2012-06 Impact factor: 1.107
Authors: Kim D Jones; Fay B Horak; Kerri Winters-Stone; Jessica Morea Irvine; Robert M Bennett Journal: J Clin Rheumatol Date: 2009-02 Impact factor: 3.517
Authors: Kim D Jones; Christy A Sherman; Scott D Mist; James W Carson; Robert M Bennett; Fuzhong Li Journal: Clin Rheumatol Date: 2012-05-13 Impact factor: 2.980