Literature DB >> 18240064

Biomarkers of HIV related central nervous system disease.

Bruce James Brew1, Scott Lee Letendre.   

Abstract

In this review we critically assess biomarkers of the direct effects of HIV related brain disease. This area is becoming increasingly complex because of the presence of confounds and varying degrees of activity of HIV brain disease. Sensitive and specific biomarkers are urgently needed although existing biomarkers do have some utility. The review will focus on the practical implications of the more established biomarkers. We discuss blood, cerebrospinal fluid and neurophysiological biomarkers but not neuroimaging techniques as they are beyond the scope of this review.

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Year:  2008        PMID： 18240064     DOI： 10.1080/09540260701878082

Source DB:  PubMed          Journal:  Int Rev Psychiatry        ISSN： 0954-0261


  29 in total

Review 1.  Brain dysfunction in the era of combination antiretroviral therapy: implications for the treatment of the aging population of HIV-infected individuals.

Authors:  Uraina S Clark; Ronald A Cohen
Journal:  Curr Opin Investig Drugs       Date:  2010-08

2.  PrPC, the cellular isoform of the human prion protein, is a novel biomarker of HIV-associated neurocognitive impairment and mediates neuroinflammation.

Authors:  Toni K Roberts; Eliseo A Eugenin; Susan Morgello; Janice E Clements; M Christine Zink; Joan W Berman
Journal:  Am J Pathol       Date:  2010-08-19       Impact factor: 4.307

3.  The current understanding of overlap between characteristics of HIV-associated neurocognitive disorders and Alzheimer's disease.

Authors:  Leah H Rubin; Erin E Sundermann; David J Moore
Journal:  J Neurovirol       Date:  2019-01-22       Impact factor: 2.643

4.  Human immunodeficiency virus-associated dementia: a link between accumulation of viral proteins and neuronal degeneration.

Authors:  Italo Mocchetti; Alessia Bachis; Giuseppe Esposito; Scott R Turner; Francesca Taraballi; Ennio Tasciotti; Mikell Paige; Valeriya Avdoshina
Journal:  Curr Trends Neurol       Date:  2014

5.  Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions.

Authors:  Khutso M Mothapo; J Ten Oever; P Koopmans; F F Stelma; S Burm; J Bajramovic; M M Verbeek; M G Olde Rikkert; M G Netea; G Koopman; A J van der Ven
Journal:  J Neurovirol       Date:  2016-11-23       Impact factor: 2.643

6.  Plasma sCD14 is a biomarker associated with impaired neurocognitive test performance in attention and learning domains in HIV infection.

Authors:  Jennifer L Lyons; Hajime Uno; Petronela Ancuta; Anupa Kamat; David J Moore; Elyse J Singer; Susan Morgello; Dana Gabuzda
Journal:  J Acquir Immune Defic Syndr       Date:  2011-08-15       Impact factor: 3.731

7.  Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection.

Authors:  Alex K Bryant; David J Moore; Tricia H Burdo; Jessica R Lakritz; Ben Gouaux; Virawudh Soontornniyomkij; Cristian L Achim; Eliezer Masliah; Igor Grant; Andrew J Levine; Ronald J Ellis
Journal:  AIDS       Date:  2017-04-24       Impact factor: 4.177

8.  Protein-free efavirenz concentrations in cerebrospinal fluid and blood plasma are equivalent: applying the law of mass action to predict protein-free drug concentration.

Authors:  L B Avery; N Sacktor; J C McArthur; C W Hendrix
Journal:  Antimicrob Agents Chemother       Date:  2013-01-07       Impact factor: 5.191

Review 9.  HIV and aging: effects on the central nervous system.

Authors:  Silvia Cañizares; Mariana Cherner; Ronald J Ellis
Journal:  Semin Neurol       Date:  2014-04-08       Impact factor: 3.420

10.  Neurocognitive dysfunction in HIV-infected youth: investigating the relationship with immune activation.

Authors:  Allison Ross Eckard; Julia C Rosebush; Mary Ann O'Riordan; Chanda C Graves; Ashley Alexander; Anita K Grover; S Thera Lee; Jakob G Habib; Joshua H Ruff; Ann Chahroudi; Grace A McComsey
Journal:  Antivir Ther       Date:  2017
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